Results 91 to 100 of about 9,794 (211)

Experimental Evidence for a Metal‐Related Function of a Cyanobactin

Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.
Cyanobactins such as patellamides are produced by cyanobacteria profusely and have been studied extensively, but almost exclusively for their cytotoxic properties. Discussed is unprecedented experimental evidence for a metal‐related biological function – likely CO2 transport from the ascidian to the cyanobacterial symbiont.
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source

Development of a Brain‐Penetrant Nurr1 Agonist Tool

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Nuclear receptor‐related 1 (Nurr1) is a ligand‐activated transcription factor with neuroprotective properties, thought to hold therapeutic potential in neurodegeneration. Here, we developed a potent, brain‐penetrant Nurr1 agonist to study the effects of pharmacological Nurr1 activation in the CNS in vivo. The ligand‐sensing transcription factor nuclear
Jan Vietor, Tanja Stiller, Christian Gege, Wael Saeb, Úrsula López‐García, Hella Kohlhof, Daniel Vitt, Daniel Merk   +7 more
wiley   +1 more source

Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou, Kalliopi Christopoulou, Amalia D. Kalampaliki, Aikaterini F. Giannopoulou, Eleftheria Chatziorfanou, Vivi Bafiti, Andreas Krämer, Athanasios Papakyriakou, Dimitrios J. Stravopodis, Stefan Knapp, Ioannis K. Kostakis   +10 more
wiley   +1 more source

Methyl (1aRS,7aSR)-7-formyl-1a-phenyl-1,1a-dihydroazirino[2,3-b]benzo[e][1,4]thiazine-7a(7H)-carboxylate

Molbank
The first representative of the aziridine-fused benzo[e][1,4]thiazine series was synthesized from methyl 2-bromo-2-phenyl-2H-azirine-2-carboxylate and benzo[d]thiazole in 74% yield.
Ilya P. Filippov, Anastasiya V. Agafonova, Nikolai V. Rostovskii, Mikhail S. Novikov   +3 more
doaj   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Cross‐Layer Molecular Design for Coherent Interface Passivation in Rigid and Flexible Perovskite Solar Cells

Advanced Functional Materials, Volume 36, Issue 44, 1 June 2026.
A cross‐layer passivation strategy employing molecularly designed thiazol‐5‐ylmethanamine hydrochloride (TMACl) enables coherent defect regulation at the SnO2/perovskite interface, stabilizes both layers, promotes phase‐pure α‐FAPbI3 formation, and enhances charge extraction, delivering PCEs of 26.44% in rigid and 24.72% in flexible perovskite solar ...
Fan Shen, Chenxu Zhao, Lianghui Li, Jia Xu, Jiale Chen, Xunhui Wang, Huijing Liu, Pengchen Zou, Xuewei Liu, Yao Fu, Huifang Han, Kun Lang, Yijun Wang, Yahan Wu, Xu Pan, Zhaofu Fei, Jianxi Yao   +16 more
wiley   +1 more source

Mechanisms, Design Principles, and Emerging Strategies in Supramolecular Assembly‐Enabled Circularly Polarized Room‐Temperature Phosphorescence

Aggregate, Volume 7, Issue 6, June 2026.
The Graphical Abstract summarizes the key concepts of this review, covering supramolecular assembly strategies, CPP material integration, multicolor emission, information encryption, and flexible optoelectronic applications. ABSTRACT Circularly polarized luminescence (CPL) and room‐temperature phosphorescence (RTP) materials are crucial for advanced ...
Wei Zhang, Jiang‐Hai Li, Mao‐Qin Liu, Zheng‐Mei Cheng, Ye Meng, Yang Luo, Jin‐Liang Zhuang   +6 more
wiley   +1 more source

Electronic Smoking Devices Among University Students: Usage Patterns and Chemical Composition of Inhaled Substances

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT This study investigated the prevalence of electronic smoking device (ESD) use and its associated behavioural and chemical risks among university students in Bahia, Brazil. A cross‐sectional survey was conducted with 355 students from public and private institutions through an online questionnaire between April and May 2023. Among participants,
Eduard F. Valenzuela, Raffael Silva Santos Almeida, Ivana Ferreira Simões, Aline Gonçalves Miranda, Magno Oliveira Ramos, Roberto Rodrigues Bandeira Tosta Maciel, Fernanda Warken Rosa, Aníbal de Freitas Santos Júnior   +7 more
wiley   +1 more source

MicroRNA‐Triggered Intracellular Self‐Assembly of Fluorescent Probes for Cancer Diagnosis and Therapy

ChemPhotoChem, Volume 10, Issue 6, June 2026.
We describe a self‐assembling DNA probe that integrates fluorescent miR‐21 sensing with innate immune activation. The enzyme‐free hybridization chain reaction generates long double‐stranded DNA that separates quenched TO dyes for a bright signal and acts as a cyclic GMP–AMP synthase agonist to activate stimulator of interferon gene, thereby inducing ...
Yunsong Xu, Kunihiko Morihiro, Rui Cong, Shuichiro Koga, Chae‐Eun Kim, Chan‐Gi Pack, Akimitsu Okamoto   +6 more
wiley   +1 more source

Recent advances in organic broad‐spectrum photodetection materials and devices

InfoMat, Volume 8, Issue 6, June 2026.
This review systematically outlines the evolution of organic photodetectors from fullerene‐based to advanced non‐fullerene acceptors, highlighting how molecular engineering (e.g., D–A, quinoidal, and A‐D‐A′‐D‐A architectures) extends spectral response into the short‐wave infrared region.
Yilin Zhao, Shijia Tan, Deyang Ji, Wenping Hu   +3 more
wiley   +1 more source