Results 71 to 80 of about 38,393 (221)

Evidence of mature adipocyte proliferation regulated by proliferin [PDF]

, 2010
Despite much research, whether mature adipocytes proliferate remains controversial. Here, we examined 5-bromo-2′-deoxyuridine (BrdU)-labelling of mature adipocytes.
Aki Minami, Hideyuki Okada, Hiroyuki Morita, Ichiro Mori, Isao Nagano, Kazuo Kajita, Kei Fujioka, Masahiro Yamauchi, Masao Takemura, Mitsuru Seishima, Takahide Ikeda, Takayuki Hanamoto, Tatsuo Ishizuka, Toshiko Kajita, Wu Zhiliang, Yoshihiro Uno, Yuzo Takahashi   +16 more
core   +1 more source

PatientExploreR: an extensible application for dynamic visualization of patient clinical history from electronic health records in the OMOP common data model. [PDF]

, 2019
MotivationElectronic health records (EHRs) are quickly becoming omnipresent in healthcare, but interoperability issues and technical demands limit their use for biomedical and clinical research.
Attali, Atul J Butte, Badgeley, Benjamin S Glicksberg, Bethany Percha, Boris Oskotsky, Chang, Debajyoti Datta, Duke, Estiri, Eugenia Rutenberg, Frankovich, Glicksberg, Hirsch, Hripcsak, Hripcsak, Huser, Jensen, Joel T Dudley, Jonathan Wren, Kipp W Johnson, Krause, Levine, Li Li, Malik, Mandel, Marcus A Badgeley, Mark M Shervey, Nadav Rappoport, Nelson Lee, Nicholas Giangreco, Nicholas P Tatonetti, Perer, Phyllis M Thangaraj, Pivovarov, Rajkomar, Remi Frazier, Riccardo Miotto, Rick Larsen, Rind, Schuemie, Shaddox, Sharat Israni, Sievert, Soulakis, Theodore C Goldstein, Vashisht, Vivek A Rudrapatna, West, Zhang   +49 more
core   +2 more sources

Adipose Tissue‐Targeted Delivery of Rosiglitazone With Iron Oxide Nanoparticles Ameliorates Insulin Resistance in Male Mice

Obesity, EarlyView.
ABSTRACT Objective This study aimed to assess iron oxide magnetic nanoparticles (MNPs) for adipose tissue‐targeted therapeutics to restore adipose tissue function and insulin sensitivity in obesity. Methods The insulin‐sensitizing effects of rosiglitazone and known adverse effects were leveraged for this proof‐of‐concept assessment of adipose tissue ...
Jakob E. Ostberg, Zeeshan Ahmed, Katayoun Saatchi, Parleen K. Pandher, Yamna Rahim, Urs O. Häfeli, Sarah L. Gray   +6 more
wiley   +1 more source

Efficacy and Safety of High-Dose Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial [PDF]

Diabetes & Metabolism Journal
Background This study investigated the efficacy and safety of pioglitazone 30 mg/day add-on to inadequately controlled type 2 diabetes mellitus (T2DM) patients with treatment of dapagliflozin and metformin.
Jun Hwa Hong, Kyung Ah Han, You-Cheol Hwang, Eun-Gyoung Hong, Hae Jin Kim, Chang Beom Lee, Ho Chan Cho, Jong Chul Won, Hun-Sung Kim, Eui-Hyun Kim, Gwanpyo Koh, Kwang Hyun Ahn, Kyong Soo Park   +12 more
doaj   +1 more source

High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes [PDF]

, 2018
Purpose: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation.
Carnevale, V., Filardi, Tiziana, Lenzi, A., Massoud, R., Morano, S., Nieddu, L., Romagnoli, E., Russo, C., Tavaglione, F., Turinese, Irene   +9 more
core   +1 more source

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

How beneficial are thiazolidinediones for diabetes mellitus? [PDF]

, 2002
The thiazolidinediones pioglitazone (Actos) and rosiglitazone (Avandia) are effective at lowering fasting plasma glucose (FPG) and glycosylated hemoglobin (Hb A1c) in patients with type 2 diabetes when used either as monotherapy or in combination with ...
Culhane, Nicole S., Graves, Rebecca S.
core  

Efficacy and safety of switching to iGlarLixi from premixed insulin therapy in patients with type 2 diabetes: A real‐world experience

Diabetic Medicine, EarlyView.
Abstract Aims Fixed‐ratio combinations such as iGlarLixi are recommended over premixed insulin as first‐line injectable therapy for type 2 diabetes mellitus (T2DM), yet real‐world evidence on transitions from premix to iGlarLixi remains limited. This study aimed to evaluate the efficacy and safety of switching from premixed insulin to iGlarLixi in a ...
Chun‐Jui Huang, Shun‐Jie Yang, Cheng‐Pin Cheng, Chun‐Hsing Lin, Ya‐Chun Lee, Harn‐Shen Chen   +5 more
wiley   +1 more source

Association between type 2 diabetes and site‐specific fracture risk: A systematic review and meta‐analysis of cohort studies including over 13 million participants

Diabetic Medicine, EarlyView.
Abstract Objective This review aimed to quantify the association between Type 2 Diabetes (T2D) and the risk of fracture at various anatomical sites by synthesising data from cohort studies. Methods A systematic search was conducted across Medline, Embase, CINAHL and Web of Science databases, from inception to 10 June 2025.
Sara Naderpour, Clare Gillies, Paul O'Riordan, Noushin Fahimfar, Zahra Karimi, Malihe Khoramdad, Sonia Khavere, Monica Kundu, Kamlesh Khunti, Safoora Gharibzadeh   +9 more
wiley   +1 more source

Liraglutide for the treatment of type 2 diabetes : a single technology appraisal [PDF]

, 2011
This paper presents a summary of the Evidence Review Group (ERG) report into the clinical effectiveness and cost-effectiveness of liraglutide in the treatment of type 2 diabetes mellitus, based upon the manufacturer’s submission to the National ...
Cummins, E. (Ewen), Royle, Pamela, Shyangdan, D. (Deepson), Waugh, Norman   +3 more
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