Results 71 to 80 of about 24,637 (218)

Time in range during caloric restriction in type 2 diabetes with obesity

open access: yesJournal of Diabetes Investigation, EarlyView.
ABSTRACT Introduction To evaluate glycemic changes during caloric restriction with continuous glucose monitoring (CGM)‐derived time in range (TIR) in individuals with type 2 diabetes and obesity. Materials and Methods This 12‐week single‐arm intervention consisted of 6 weeks of home‐delivered meals (800–1,200 kcal/day), followed by 6 weeks of self ...
Jinyoung Kim   +9 more
wiley   +1 more source

Cellular, Molecular Consequences of Peroxisome Proliferator- Activated Receptor-δ Activation in Ovarian Cancer Cells

open access: yesNeoplasia: An International Journal for Oncology Research, 2006
Peroxisome proliferator-activated receptor-δ (PPAR-δ) is a ligand-activated transcription factor. In addition to its canonical role in lipid, glucose metabolism, PPAR-δ controls cell proliferation, death, differentiation in several tissues.
Sara Vignati   +9 more
doaj   +1 more source

Antiatherogenic Effects of Thiazolidinediones? [PDF]

open access: yesArteriosclerosis, Thrombosis, and Vascular Biology, 2001
Treatment of type 2 diabetes mellitus (DM) is directed at relieving symptoms of hyperglycemia and reducing the incidence of diabetes-associated pathologies. Complications of atherosclerosis, including myocardial infarction and stroke, are the most common causes of death in diabetic patients.
openaire   +2 more sources

Cholesterol accumulation in monocytes is associated with the severity of diabetic complications and the efficacy of glycemic control interventions in patients with type 2 diabetes

open access: yesJournal of Diabetes Investigation, EarlyView.
This study reveals that monocyte cholesterol accumulation correlates with the severity of diabetic complications and predicts post‐discharge glycemic deterioration. These findings suggest that monocytic cholesterol serves as a novel translational biomarker reflecting ‘metabolic memory’ and therapeutic resistance in patients with type 2 diabetes ...
Hideyuki Okuma   +3 more
wiley   +1 more source

Long-term results of transferring the patient from therapy with glucagon-like peptide-1 receptor agonists in combination with metformin to a dipeptidyl peptidase-4 inhibitor in combination with pioglitazone and inhibitor of type 2 sodium-glucose cotransporter in type 2 diabetes

open access: yesСахарный диабет
The pioglitazone belongs to the class of antidiabetic medications and has various pleiotropic effects. The evidence base for this medication, based on the results of randomized clinical trials, demonstrates convincing cardio- and cerebroprotective ...
V. V. Salukhov   +2 more
doaj   +1 more source

Association of Antihyperglycemic Therapy with Risk of Atrial Fibrillation and Stroke in Diabetic Patients

open access: yesMedicina, 2019
Type 2 diabetes mellitus (DM) is associated with an increased risk of cardiovascular disease (CVD). Atrial fibrillation (AF) and stroke are both forms of CVD that have major consequences in terms of disabilities and death among patients with diabetes ...
Cristina-Mihaela Lăcătușu   +5 more
doaj   +1 more source

Effect of sodium–glucose cotransporter 2 inhibitors on heart failure readmission in older patients with diabetes: A Japanese claims‐based cohort study

open access: yesJournal of Diabetes Investigation, EarlyView.
SGLT2 inhibitor use at discharge was associated with a reduced risk of heart failure readmission in elderly patients with diabetes, with no significant differences among individual agents. ABSTRACT Aims To evaluate the effect of sodium–glucose cotransporter 2 inhibitor (SGLT2i) administration at hospital discharge on heart failure (HF) readmission ...
Kazuya Hiura   +3 more
wiley   +1 more source

Thiazolidinediones and risk of colorectal cancer in patients with diabetes mellitus: A meta-analysis

open access: yesThe Saudi Journal of Gastroenterology, 2018
Background/Aims: A growing body of evidence has suggested that thiazolidinediones (TZDs) potentially reduce the risk of colorectal cancer (CRC). This study aimed to evaluate the effect of TZDs on CRC risk in patients with diabetes mellitus (DM). Patients
Yang Liu   +3 more
doaj   +1 more source

Primary cardiovascular preventive effect of thiazolidinedione in adults with type 2 diabetes: A nationwide cohort study in Korea

open access: yesJournal of Diabetes Investigation, EarlyView.
Among Korean adults with type 2 diabetes and no prior cardiovascular disease, thiazolidinedione use was associated with a lower risk of the primary composite outcome of stroke, myocardial infarction, hospitalization for heart failure, and all‐cause mortality compared to dipeptidyl peptidase‐4 inhibitor use. ABSTRACT Background Thiazolidinediones (TZDs)
Yun Young Choi   +4 more
wiley   +1 more source

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