Results 41 to 50 of about 2,743 (163)

4-Methyl-N-[(Z)-3-(4-methylphenylsulfonyl)-1,3-thiazolidin-2-ylidene]benzenesulfonamide

Acta Crystallographica Section E, 2011
In the crystal structure of the title compound, C17H18N2O4S3, molecules are connected into centrosymmetric dimers via weak intermolecular C—H...π interactions.
Hui-Ling Hu, Geng-Ren Yang, Chun-Wei Yeh
doaj   +1 more source

Syntheses of New Unsymmetrical and Symmetrical Diarylsulphides and Diarylsulphones Containing Thiazolinyl and Thiazolidinonyl Moieties Using 4,4'-Diacetyldiphenylsulphide

Molecules, 2003
Condensation of 4,4’-diacetyldiphenyl sulphide (2) with variable amounts of thiosemicarbazide (3) in refluxing ethanol and in the presence of catalytic amounts of dry piperidine afforded only 4-acetylthiosemicarbazone-4’-acetyldiphenyl sulphide
M. I. Abdel-Monem, M. M. Kandeel, Sh. H. Abdel-Hafez, M. A. Abbady   +3 more
doaj   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance [PDF]

Anais da Academia Brasileira de Ciências, 2019
: Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods.
KARINA M.S. HERRERA, LORENA S. FERREIRA, ALYSSON V. BRAGA, JULIANO P. SOUZA, JÉSSICA T. ANDRADE, ADRIANA C. SOARES, LUIS F. SOARES, RAFAEL C.R. CHAGAS, JAQUELINE M.S. FERREIRA   +8 more
doaj   +1 more source

Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines

Angewandte Chemie International Edition, 2010
A good imitation: Di- and trisaccharide analogues of the oxazoline intermediate formed during enzymatic hydrolysis of chitin were found to be potent inhibitors of chitinase A. The high affinity and enzymatic stability of a readily synthesized thioamide trisaccharide (two molecules of which are shown in the enzyme active site), and the mechanism-based ...
James M. Macdonald, Chris A. Tarling, Edward Taylor, Rebecca J. Dennis, David S. Myers, Spencer Knapp, Gideon J. Davies, Stephen G. Withers   +7 more
openaire   +2 more sources

Protein O‐GlcNAcylation in Health and Diseases

MedComm, Volume 6, Issue 12, December 2025.
We first introduced the beneficial effects of normal protein O‐GlcNAcylation on health, impacting biological processes such as gene expression, cell cycle progression, metabolism, and signal transduction. Next, we described the role of abnormal protein O‐GlcNAcylation in the development and progression of diseases, including neurodegenerative diseases,
Zhihong Ran, Chuanbao Chen, Jingfeng Ou, Guanyi Wu, Chao Yang, Xiaoyou Liu   +5 more
wiley   +1 more source

Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A series of 3-3-{2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dihydro-1H-indol-2-one derivatives has been designed and synthesized to study their activity on both HIV-1 (Human Immunodeficiency Virus type 1) RT (Reverse ...
Rita Meleddu, Simona Distinto, Angela Corona, Enzo Tramontano, Giulia Bianco, Claudia Melis, Filippo Cottiglia, Elias Maccioni   +7 more
doaj   +1 more source

2-(6-Bromobenzo[d]thiazol-2-yl)-5,5-dimethylthiazol-4(5H)-one

Acta Crystallographica Section E, 2013
The title compound, C12H9BrN2OS2, was obtained by reacting 6-bromobenzo[d]thiazole-2-carbonitrile in iso-propanol with ethyl 2-mercapto-2-methylpropanoate at reflux temperature for several hours.
Rainer Beckert, Dieter Weiss, Helmar Görls, Hendryk Würfel   +3 more
doaj   +1 more source

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

ChemBioChem, Volume 26, Issue 21, November 8, 2025.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler, Anshul Rajput, Jonathan R. Chekan   +2 more
wiley   +1 more source

Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A. [PDF]

PLoS ONE, 2009
Endo-beta-N-acetylglucosaminidases (ENGases) are dual specificity enzymes with an ability to catalyze hydrolysis and transglycosylation reactions. Recently, these enzymes have become the focus of intense research because of their potential for synthesis ...
Jie Yin, Lei Li, Neil Shaw, Yang Li, Jing Katherine Song, Wenpeng Zhang, Chengfeng Xia, Rongguang Zhang, Andrzej Joachimiak, Hou-Cheng Zhang, Lai-Xi Wang, Zhi-Jie Liu, Peng Wang   +12 more
doaj   +1 more source