Results 41 to 50 of about 810,413 (280)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Improved Electromagnetic Interference Shielding Properties of MWCNT–PMMA Composites Using Layered Structures

Nanoscale Research Letters, 2009
Electromagnetic interference (EMI) shielding effectiveness (SE) of multi-walled carbon nanotubes–polymethyl methacrylate (MWCNT–PMMA) composites prepared by two different techniques was measured. EMI SE up to 40 dB in the frequency range 8.2&#
Saini P, Dhawan SK, Pande Shailaja, Singh BP, Mathur RB, Dhami TL   +5 more
doaj   +1 more source

Effect of weight percentage of B4C reinforcement on physical and mechanical properties of polyamide 6/polystyrene composites

Journal of Taibah University for Science, 2020
Blends of polyamide 6/polystyrene (PA6/PS) (50/50 wt./wt. %) were loaded with different concentrations of boron carbide (B4C), (0, 5, 10, 15, 20 and 30 wt./wt. %) separately for EMI shielding.
N. I. Aljuraide, A. M. Abd Elbary
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Thick composite design for hydrogen vessels: A contribution to composite design method [PDF]

CIRP Annals, 2013
Abstract Hydrogen stock vessels add new product specifications because of higher pressure use. Today static application leads up to 700 bars. But pressure devices must resist, because of certification, at 3 times pressure (2100 bars). Composite vessels give material–structure potential solutions.
Perry, Nicolas, Wahl, Jean-Christophe, Bois, Christophe, Pilato, Aurélie, Bernard, Alain   +4 more
openaire   +4 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Impact response and failure behavior of adhesive-bonded aluminum-wood lightweight composites

Journal of Materials Research and Technology
Metal-wood composites are promising lightweight materials for substituting traditional steels or aluminum alloys in automotive applications. This study investigates the pendulum impact response of 4 mm-thick solid birch plates and laminates made of 1 mm ...
Eva Graf, Georg Baumann, Sebastian Wurm, Florian Feist, Christof Sommitsch, Josef Domitner   +5 more
doaj   +1 more source