Results 61 to 70 of about 143,763 (308)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Carbon nanotubes and silver flakes filled epoxy resin for new hybrid conductive adhesives [PDF]

, 2011
Combining conductive micro and nanofillers is a new way to improve electrical conductivity. Micrometric silver flakes and nanometric carbon nanotubes (CNTs) exhibit high electrical conductivity.
Courtade, Frédéric, Demont, Philippe, Falat, Tomasz, Jamin, Thierry, Laurent, Christophe, Marcq, Fabien, Monfraix, Philippe, Peigney, Alain   +7 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Empirical analysis of the solar contribution to global mean air surface temperature change [PDF]

, 2009
The solar contribution to global mean air surface temperature change is analyzed by using an empirical bi-scale climate model characterized by both fast and slow characteristic time responses to solar forcing: $\tau_1 =0.4 \pm 0.1$ yr, and $\tau_2= 8 \pm
Brohan, Crowley, Douglass, Eddy, Eichler, Fröhlich, Fröhlich, Gleisner, Hansen, Hegerl, Hegerl, Hoyt, Kirkby, Knutti, Krivova, Lean, Lockwood, Loehle, Mann, Moberg, Nicola Scafetta, North, North, Scafetta, Scafetta, Scafetta, Scafetta, Scafetta, Scafetta, Schwartz, Shaviv, van Loon, Wang, White, Wigley, Willson   +35 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Influence of nanotube length and density on the plasmonic terahertz response of single-walled carbon nanotubes [PDF]

, 2017
We measure the conductivity spectra of thin films comprising bundled single-walled carbon nanotubes (CNTs) of different average lengths in the frequency range 0.3-1000 THz and temperature interval 10-530 K. The observed temperature-induced changes in the
Beckerleg, Chris, Hendry, Euan, Karlsen, Peter, Ksenevich, Vitaly, Kuzhir, Polina P., Maksimenko, Sergey A., Nasibulin, Albert G., Shuba, Mikhail V., Tenne, Reshef, Viet, Ho, Yuko, Dzmitry I.   +10 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Experimental investigation of thickness effects in the manufacture of thick-section composite structures using liquid thermoplastic resin

Advanced Manufacturing: Polymer & Composites Science
Thick-section composites (10–100 mm) are increasingly used in structurally demanding applications. Growing interest in sustainable alternatives has driven the development of recyclable, room-temperature-processable liquid thermoplastic resins to replace ...
Ione L. M. Smith, Edward D. McCarthy, Philipp R. Thies, Selda Oterkus, Winifred Obande   +4 more
doaj   +1 more source

The Tribological and Sealing Properties of PFA Composites

International Journal of Polymer Science, 2018
The polytetrafluoroethylene (PTFE) and perfluoroalkoxyperfluoropropyl vinyl ether (PFA) composites were prepared using carbon fiber (CF) and glass fiber (GF) as fillers.
Ye Sujuan, Yu Quan, Li Kunquan, Tan Feng, Fan Qing, Tan Guibin, Huang Xing   +6 more
doaj   +1 more source

Numerical modelling of compaction induced defects in thick 2D textile composites

Materials & Design, 2020
This paper introduces a novel approach to include the high transverse compliance of textile materials into conventional forming simulations, allowing for the compaction process of thick 2D textile composites to be simulated.
Adam J. Thompson, Joseph R. McFarlane, Jonathan P.-H. Belnoue, Stephen R. Hallett   +3 more
doaj   +1 more source