Results 21 to 30 of about 190,891 (262)
Geophysical Journal International, 1983 Analytical expressions are derived for the displacements and stresses due to loading of a floating, uniform, elastic plate of arbitrary thickness by a plane or axisymmetric harmonic load. The solution is exact except for assumptions of small strains and linear boundary conditions, and gravitation within the plate is neglected.
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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Teshugang, 2020 According to the requirements of 200 mm extra thick 12Cr2MolR steel plate for hydrogen chemical industry i. e.P ≤0.007% ,Si≤0. 1% , brittleness index J≤100X≤10x10-6by the electroslag remelting technology of 120 t BOF-LF-VD-continuous bloom and the heat ...
尹卫江 +6 more
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
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Polish Maritime Research, 2015 Thin and thick plates, plates with holes, stiffened panels and stiffened panels with holes are primary structural members in almost all fields of engineering: civil, mechanical, aerospace, naval, ocean etc. In this paper, a simple and efficient procedure
Cho Dae Seung +2 more
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A Novel Exact Plate Theory for Bending Vibrations Based on the Partial Differential Operator Theory
Mathematics, 2021 Thick wall structures are usually applied at a highly reduced frequency. It is crucial to study the refined dynamic modeling of a thick plate, as it is directly related to the dynamic mechanical characteristics of an engineering structure or device ...
Chuanping Zhou +5 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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Zhongguo Jianchuan YanjiuObjectivesTo solve the problem of applying thick carbon fiber laminates in naval architecture and marine engineering, this paper proposes a thick plate structure composed of thin carbon fiber laminates with reinforcing ribs and core material in the ...
Hao TONG, Yuchao YUAN, Wenyong TANG
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
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Arid Zone Journal of Engineering, Technology and Environment, 2021 This study presents the application of a new refined plate theory in the bending analysis of a thick rectangular plate carrying a uniformly distributed load using the direct energy method.
F. C. Onyeka, T. E. Okeke
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