Results 31 to 40 of about 190,891 (262)

VIBRATION ANALYSIS OF STEPPED THICKNESS PLATES [PDF]

open access: yesJournal of Sound and Vibration, 1997
Investigation has been made into various approaches for analyzing the vibration of plates with stepped thicknesses. First, attention has been paid to updating a classical approach for the analysis of such problems, correcting the boundary conditions cited in an earlier paper and dealing with the difficulties that can arise when calculating high order ...
Guo, S.J.   +2 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A new finite element formulation for vibration analysis of thick plates

open access: yesInternational Journal of Naval Architecture and Ocean Engineering, 2015
A new procedure for determining properties of thick plate finite elements, based on the modified Mindlin theory for moderately thick plate, is presented.
Ivo Senjanović   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ANALYSIS OF BENDING OF THICK RECTANGULAR PLATES: A REVIEW

open access: yesAcademy Journal of Science and Engineering
Thick rectangular plates are widely used in engineering, and it is crucial for engineers to analyze their structural behavior under bending for improved design and construction.
Uchechi Eziefula   +3 more
doaj   +1 more source

Plating thickness standards [PDF]

open access: yes, 1979
A variety of standards that have been developed and fabricated for the nondestructive measurement of plating thickness are listed. The development and fabrication of TiB/sub 2/-on-steel thickness standards are described. Pure-copper-foil reference units were provided for use in the four-point resistance measurement of copper-on-epoxy-board plating ...
openaire   +2 more sources

General Relativistic Fall on a Thick-Plate

open access: yesInternational Journal of Theoretical Physics, 2023
11 pages, 1 ...
Halilsoy, M., Memari, V.
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Accurate Numerical Solutions for Standard Skew Plate Benchmark Problems

open access: yesZbornik Radova, 2022
Morley’s skew plate and Razzaque’s skew plate are two standard benchmark problems used for the performance evaluation of plate finite elements. The reference solutions for these problems are given for the thin plate case only, and various plate finite ...
Marin Grbac, Dragan Ribarić
doaj   +1 more source

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