Results 31 to 40 of about 6,351,452 (282)

Bending Analysis of Thick Isotropic Plates by Using 5th Order Shear Deformation Theory [PDF]

open access: yesJournal of Applied and Computational Mechanics, 2016
A 5th order shear deformation theory considering transverse shear deformation effect as well as transverse normal strain deformation effect is presented for static flexure   analysis of simply supported isotropic plate.
Yuwaraj M. Ghugal, Param D. Gajbhiye
doaj   +1 more source

Buckling of orthotropic plates with bimoments

open access: yesИнженерно-строительный журнал, 2015
The paper is dedicated to improvement of plate theory in order to take into account forces, moments and bimoments, generated by nonlinear law of displacement distribution in plate cross-sections.
M.K. Usarov
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

On boundary layer in the Mindlin plate model: Levy plates [PDF]

open access: yes, 2008
This work is related to the bending problem of thick rectangular Levy plates. Series solution for the Mindlin (thick) plate model is obtained and represented as a sum of the Kirchhoff (thin) plate model solution, the ``shear terms'' and the ``boundary ...
Brank, Boštjan
core  

A size-dependent functionally graded sinusoidal plate model based on a modified couple stress theory [PDF]

open access: yes, 2013
A size-dependent model for bending and free vibration of functionally graded plate is developed based on the modified couple stress theory and sinusoidal shear deformation theory.
Thai, Huu-Tai, Vo, Thuc
core   +1 more source

Application of the Method of Initial Functions to Study Dynamics and Stress Distribution in Structural Members

open access: yesAdvances in Civil Engineering
This study investigates plate analyses employing the method of initial functions (MIFs) across various plate geometries and loading conditions. The conclusions derived from thick rectangular plates highlight substantial thickness-induced effects on ...
Jitendra Namdeo   +3 more
doaj   +1 more source

A 16-node locking-free Mindlin plate resting on two-parameter elastic foundation- static and eigenvalue analysis

open access: yesComputer Assisted Methods in Engineering and Science, 2017
The Pasternak elastic foundation model is employed to study the statics and natural frequencies of thick plates in the framework of the finite element method.
Ryszard Buczkowski   +2 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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