Results 181 to 190 of about 1,360 (195)
Some of the next articles are maybe not open access.
Thienamycin. A solution of the stereochemical problem
Tetrahedron Letters, 1979Abstract A new nitrone-based synthesis of β-lactams is described which makes provision for the 1-hydroxyethyl moiety in the potent antibiotic thienamycin. Moreover, the relative stereochemical features of the natural product are defined in a step involving the cycloaddition of a nitrone with methyl crotonate.
Joseph J. Tufariello +3 more
openaire +1 more source
Imipenem: The First Thienamycin Antibiotic
Clinical Infectious Diseases, 1985A M, Geddes, W, Stille
openaire +4 more sources
Imipenem: the first thienamycin antibiotic.
Postgraduate medical journal, 1987Imipenem is a new beta-lactam which differs chemically from penicillins and cephalosporins but has a similar mode of action. It is a potent antibacterial agent with a broad spectrum of activity encompassing both aerobes and anaerobes. However, in vitro, it does not appear to offer a great improvement over other available agents for the treatment of ...
openaire +1 more source
In vitro activity of thienamycin.
Methods and findings in experimental and clinical pharmacology, 1982The in vitro activity of thienamycin was determined simultaneously in Müller-Hinton broth and peptone broth. Minimum inhibitory and bactericidal concentrations were compared to those of 4 aminoglycosides and 3 cefalosporins. The activity of thienamycin against gram-negative aerobic bacterial was influenced by the media.
openaire +1 more source
[N-Formimidoyl-thienamycin in Animal Studies].
Arzneimittel-Forschung, 1983The beta-lactam antibiotic thienamycin is rather unstable and is metabolized in man by renal dehydropeptidase-I. The derivatives of the antibiotic, especially N-formimidoyl-thienamycin (MK-0787) are reported to be more resistant. The antibacterial activity of N-formimidoyl-thienamycin was tested by means of the infection- and therapy model of the acute,
openaire +2 more sources
Thienamycin total synthesis. 3. Total synthesis of (.+-.)-thienamycin and (.+-.)-8-epithienamycin
The Journal of Organic Chemistry, 1980Susan M. Schmitt +2 more
openaire +1 more source
Total synthesis of (.+-.)-thienamycin
Journal of the American Chemical Society, 1978David B. R. Johnston +3 more
openaire +1 more source
A stereocontrolled synthesis of (+)-thienamycin
Journal of the American Chemical Society, 1980Thomas N. Salzmann +3 more
openaire +1 more source