Results 11 to 20 of about 1,360 (195)

International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 8, Page 740-777, August 2023., 2023
Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well established to display time‐dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug ...
Lisa T. Hong, Kevin J. Downes, Alireza FakhriRavari, Jacinda C. Abdul‐Mutakabbir, Joseph L. Kuti, Sarah Jorgensen, David C. Young, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Mark Gilchrist, Soo Min Jang, Thomas Lodise, Jason A. Roberts, Thomas Tängdén, Athena Zuppa, Marc H. Scheetz   +16 more
wiley   +1 more source

Dissemination of carbapenemase‐producing Enterobacteriaceae and associated resistance determinants through global food systems

Comprehensive Reviews in Food Science and Food Safety, Volume 22, Issue 4, Page 2706-2727, July 2023., 2023
Abstract Antimicrobial agents are a critical component of modern healthcare systems, fulfilling a core function in patient care and improving individual patient outcomes and consequently overall public health. However, the efficacy of antimicrobial interventions is being consistently eroded by the emergence and dissemination of various antimicrobial ...
Richard Harding‐Crooks, Darren Smith, Séamus Fanning, Edward M. Fox   +3 more
wiley   +1 more source

Environmental hotspots for antibiotic resistance genes

MicrobiologyOpen, Volume 10, Issue 3, June 2021., 2021
Antibiotic contamination or waste enters a variety of different environmental settings. The accumulation of antibiotics ​can cause a selective pressure on bacteria that encode resistance genes for their survival, generating a hotspot for resistance genes.
Shalini Kunhikannan, Colleen J. Thomas, Ashley E. Franks, Sumana Mahadevaiah, Sumana Kumar, Steve Petrovski   +5 more
wiley   +1 more source

The war against bacteria, from the past to present and beyond [PDF]

, 2021
Introduction: : The human defense against microorganisms dates back to the ancient civilizations, with attempts to use substances from vegetal, animal or inorganic origin to fight infections.
Bottalico, Lucrezia, Charitos, Ioannis Alexandros, Montagnani, Monica, Potenza, Maria Assunta, Santacroce, Luigi   +4 more
core   +1 more source

Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity [PDF]

, 2012
A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material.
Samadhiya Pushkal, Sharma Ritu, Srivastava Santosh K., Srivastava Savitri D.   +3 more
core   +1 more source

Interventions to improve antibiotic prescribing practices for hospital inpatients [PDF]

, 2017
Background Antibiotic resistance is a major public health problem. Infections caused by multidrug-resistant bacteria are associated with prolonged hospital stay and death compared with infections caused by susceptible bacteria. Appropriate antibiotic use
Brown, Erwin, Charani, Esmita, Davey, Peter, Gould, Ian M., Marwick, Charis A., McNeil, Kirsty, Michie, Susan, Ramsay, Craig R., Scott, Claire L.   +8 more
core   +3 more sources

Prophylactic antibiotics for penetrating abdominal trauma [PDF]

, 2019
BACKGROUND : Penetrating abdominal trauma occurs when the peritoneal cavity is breached. Routine laparotomy for penetrating abdominal injuries began in the 1800s, with antibiotics first being used in World War II to combat septic complications ...
Brand, Martin, Grieve, Andrew
core   +1 more source

Synthesis, x-ray crystal structures and biological evaluation of some mono- and bi-cyclic 1,3-diazetidin-2-ones: non-natural β -lactam analogues [PDF]

, 1998
Mono- and bi-cyclic 1,3-diazetidin-2-ones (aza-β -lactams) are synthesised and evaluated as non-natural analogues of β -lactams. The aza-β -lactams are designed on the principle that their reaction with active site serine hydroxy will form
Chandrakala, P. S., Desiraju, Gautam R., Katz, Amy K., Nangia, Ashwini, Podile, A. R., Sailaja, P. R.   +5 more
core   +1 more source

Imipenem and Meropenem: Comparison of In Vitro Activity, Pharmacokinetics, Clinical Trials and Adverse Effects

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 9, Issue 4, Page 215-228, 1998., 1997
OBJECTIVE: To compare and contrast imipenem and meropenem in terms of in vitro activity, pharmacokinetics, clinical efficacy and adverse effects. DATA SELECTION: MEDLINE search from 1975 to 1997 and follow‐up of references. DATA EXTRACTION: Clinical trials comparing imipenem with meropenem, or either imipenem or meropenem with standard therapy in the ...
George G Zhanel, Andrew E Simor, Lavern Vercaigne, Lionell Mandell, the Canadian Carbapenem Discussion Group   +4 more
wiley   +1 more source

Drug utilization study of two generic antibiotics in a tertiary hospital in Bogotá [PDF]

, 2018
Introduction: The Colombian national pharmaceutical policy establishes as a strategy the generation of greater pharmaco-epidemiological research at the national level, especially in the case of antibiotic drugs.
Claudia Marcela Vargas-Peláez, Francisco Rossi, José Julián López, Yira Cortázar, Ángela Acosta   +4 more
core   +2 more sources