Results 11 to 20 of about 870 (107)
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 8, Page 740-777, August 2023., 2023 Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well established to display time‐dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug ...
Lisa T. Hong +16 more
wiley +1 more source
Comprehensive Reviews in Food Science and Food Safety, Volume 22, Issue 4, Page 2706-2727, July 2023., 2023 Abstract Antimicrobial agents are a critical component of modern healthcare systems, fulfilling a core function in patient care and improving individual patient outcomes and consequently overall public health. However, the efficacy of antimicrobial interventions is being consistently eroded by the emergence and dissemination of various antimicrobial ...
Richard Harding‐Crooks +3 more
wiley +1 more source
Environmental hotspots for antibiotic resistance genes
MicrobiologyOpen, Volume 10, Issue 3, June 2021., 2021 Antibiotic contamination or waste enters a variety of different environmental settings. The accumulation of antibiotics can cause a selective pressure on bacteria that encode resistance genes for their survival, generating a hotspot for resistance genes.
Shalini Kunhikannan +5 more
wiley +1 more source
Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 9, Issue 4, Page 215-228, 1998., 1997 OBJECTIVE: To compare and contrast imipenem and meropenem in terms of in vitro activity, pharmacokinetics, clinical efficacy and adverse effects. DATA SELECTION: MEDLINE search from 1975 to 1997 and follow‐up of references. DATA EXTRACTION: Clinical trials comparing imipenem with meropenem, or either imipenem or meropenem with standard therapy in the ...
George G Zhanel +4 more
wiley +1 more source
Canadian Practice Guidelines for Surgical Intra‐Abdominal Infections
, 2010 Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 21, Issue 1, Page 11-37, 2010.
Anthony W Chow +8 more
wiley +1 more source
Access to β‐Lactam Sulfonamides from Sulfamoyl Chlorides via Photoredox Catalyzed C−S Bond Formation
Advanced Synthesis &Catalysis, Volume 366, Issue 15, Page 3310-3315, August 6, 2024.Abstract Sulfonyl chlorides are a synthetically attractive source of sulfonyl radicals in photoredox catalysis and are useful precursors in the synthesis of sulfones. Sulfamoyl chlorides, on the other hand, remain poorly represented despite their similar potential.
Nejc Petek +4 more
wiley +1 more source
Journal of Industrial Microbiology, 1987 A cell-free extract from the thienamycin producer,Streptomyces cattleya, has been found to deacetylate the co-product,N-acetylthienamycin. The pH optimum of the reaction is 7.5. Due to the lability ofN-acetylthienamycin, we used thed andl forms of the synthetic substrateN-chloroacetylvaline.
Masaru Uyeda, Arnold L. Demain
openaire +1 more source
Integration of Continuous Renal Replacement Therapy in a Meropenem Population Pharmacokinetics Model in Critically Ill Children. [PDF]
Antimicrob Agents Chemother, 2021 Béranger A, Bouazza N, Oualha M.
europepmc +1 more source