Results 11 to 20 of about 910 (153)
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 8, Page 740-777, August 2023., 2023 Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well established to display time‐dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug ...
Lisa T. Hong +16 more
wiley +1 more source
Comprehensive Reviews in Food Science and Food Safety, Volume 22, Issue 4, Page 2706-2727, July 2023., 2023 Abstract Antimicrobial agents are a critical component of modern healthcare systems, fulfilling a core function in patient care and improving individual patient outcomes and consequently overall public health. However, the efficacy of antimicrobial interventions is being consistently eroded by the emergence and dissemination of various antimicrobial ...
Richard Harding‐Crooks +3 more
wiley +1 more source
Environmental hotspots for antibiotic resistance genes
MicrobiologyOpen, Volume 10, Issue 3, June 2021., 2021 Antibiotic contamination or waste enters a variety of different environmental settings. The accumulation of antibiotics can cause a selective pressure on bacteria that encode resistance genes for their survival, generating a hotspot for resistance genes.
Shalini Kunhikannan +5 more
wiley +1 more source
In Vitro Activity of Thienamycin [PDF]
Antimicrobial Agents and Chemotherapy, 1978 The in vitro activity of thienamycin was tested against 135 aerobic and anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli and penicillin-resistant Straphylococcus aureus . The antianaerobic spectrum of the drug seemed to be comparable to that of metronidazole.
F P, Tally, N V, Jacobus, S L, Gorbach
openaire +2 more sources
In vitro activity of N-formimidoyl thienamycin (MK0787), a crystalline derivative of thienamycin [PDF]
Antimicrobial Agents and Chemotherapy, 1980 N-Formimidoyl thienamycin (MK0787) is a derivative of thienamycin, a unique, new beta-lactam antibiotic. Its activity against 285 aerobic and facultatively anaerobic clinical isolates was compared with the activities of cephalothin, ampicillin, penicillin G, ticarcillin, and tobramycin.
V W, Horadam +3 more
openaire +2 more sources
The war against bacteria, from the past to present and beyond [PDF]
, 2021 Introduction: : The human defense against microorganisms dates back to the ancient civilizations, with attempts to use substances from vegetal, animal or inorganic origin to fight infections.
Bottalico, Lucrezia +4 more
core +1 more source
Synthese einer chiralen Thienamycin-Vorstufe / Synthesis of a Chiral Thienamycine Intermediate [PDF]
Zeitschrift für Naturforschung B, 1987 Abstract A key intermediate of Kametani’s total synthesis of racemic thienamycine has now been prepared in chiral form via a 1.3-dipolar cycloadduct of a chiral nitrone and benzyl crotonate.
Hubert Martin, Rudolf Herrmann, Ivar Ugi
openaire +1 more source
Synthesis of 2-oxo-azetidine derivatives of 2-amino thiazole and their biological activity [PDF]
, 2012 A new series of N-[2-(2-aminothiazolyl)ethyl]-4-(substitutedphenyl)- 3-chloro-2-oxo-1-iminoazetidine, compounds 4(a-m) have been synthesized from 2-aminothiazole as a starting material.
Samadhiya Pushkal +3 more
core +1 more source
N-formimidoyl thienamycin (MK0787): in vitro study [PDF]
Antimicrobial Agents and Chemotherapy, 1981 N-Formimidoyl thienamycin (MK0787) was compared in vitro with three other beta-lactam and two aminoglycoside antibiotics. It was second in activity only to cefotaxime against members of the Enterobacteriaceae and to amikacin against Pseudomonas species. It was the most active antibiotic against Staphylococcus aureus.
S, Shadomy, R S, May
openaire +2 more sources
Interventions to improve antibiotic prescribing practices for hospital inpatients [PDF]
, 2017 Background Antibiotic resistance is a major public health problem. Infections caused by multidrug-resistant bacteria are associated with prolonged hospital stay and death compared with infections caused by susceptible bacteria. Appropriate antibiotic use
Brown, Erwin +8 more
core +3 more sources