Results 161 to 170 of about 53,903 (284)

Structure and Dynamics of the Flexible Cardiac Troponin T Linker Domain in a Fully Reconstituted Thin Filament. [PDF]

Biochemistry, 2022
Deranek AE, Baldo AP, Lynn ML, Schwartz SD, Tardiff JC.   +4 more
europepmc   +1 more source

A 3D‐Printed Blister Test Platform for Quantifying Biointerface Adhesion Mechanisms

Advanced Materials Interfaces, EarlyView.
A 3D‐printed blister platform enables energy‐resolved characterization of soft hydrogel–rigid interfaces. Integrating precision pressure control with hyperelastic modeling directly quantifies adhesion energy (G) and R‐curve toughening. Results reveal that modulating hydrogel concentration and surface roughness drives a tunable transition from cohesive ...
Yoontae Kim, Rahul Patil, Argyris K. Lazaris, Xinran Zhang, Stella Alimperti   +4 more
wiley   +1 more source

Proteomic Analysis of Thin Filament Components Elucidates Changes in Spastic Muscle Sarcomere After Stroke. [PDF]

Int J Mol Sci
He Y, Liu G, Wu J, Jiang X, Yang S.
europepmc   +1 more source

Free-Energy Surfaces of Two Cardiac Thin Filament Conformational Changes during Muscle Contraction. [PDF]

J Phys Chem B, 2022
Mason AB, Tardiff JC, Schwartz SD.
europepmc   +1 more source

Additively Manufactured Porous Ceramics as Tunable Dielectrics for Passive Temperature Sensing

Advanced Materials Technologies, EarlyView.
Porous ceramic lattices, 3D‐printed from a multicomponent oxide ink, are integrated with LC resonators for passive wireless temperature sensing. By tuning porosity, the dielectric properties and RF response are engineered to produce distinct resonant frequency shifts with temperature. The results establish a structure‐driven approach to customizing the
Sogol Heidarishahrivar, Aminul Islam, Chang Woo Gal, Insup Kim, Yeong‐Jin Choi, Woo Soo Kim   +5 more
wiley   +1 more source

Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed mouse skeletal muscle. [PDF]

Physiol Rep
Kuehn MN, Engels NM, Nissen DL, Freundt JK, Ma W, Harris SP, Irving TC, Linke WA, Hessel AL.   +8 more
europepmc   +1 more source

Computational and biophysical determination of pathogenicity of variants of unknown significance in cardiac thin filament. [PDF]

JCI Insight, 2021
Mason AB, Lynn ML, Baldo AP, Deranek AE, Tardiff JC, Schwartz SD.   +5 more
europepmc   +1 more source

Tunable 3D‐Printed Static Mixers for Gradient Bioprinting With High Cell Viability

Advanced Materials Technologies, EarlyView.
ABSTRACT The fabrication of native tissue‐like structures with gradual transitions in material properties, cell types, and growth factors remains a major challenge in biofabrication due to the lack of suitable methods. Mimicking the hierarchical organization of living tissues is essential for functional models, yet creating gradient, multimaterial ...
Florian Hofmann, Jessica Faber, Franz Moser, Alessandro Cianciosi, Nicoletta Murenu, Joachim Schenk, Katrin G. Heinze, Natascha Schaefer, Silvia Budday, Tomasz Jungst   +9 more
wiley   +1 more source

Discovery of small molecule modulators of the thin filament that alter the contractile profile in a hypertrophic cardiomyopathy engineered tissue model. [PDF]

J Biol Chem
Sommese RF, Levi SM, Brown J, Polivkova J, Byrnes LJ, Kue R, Damilano F, Hua W, Boehm M, Dushin E, Filipski KJ, Kormos BL, Li Q, Miller R, Ogilvie K, Ridgway N, Smith AC, Stansfield JC, Wang Y, Withka J, Zhang H, Griffith DA, Ward J.   +22 more
europepmc   +1 more source

Topography‐Regulated Screening Platform for Myoblast Contact Guidance

Advanced Materials Technologies, EarlyView.
This study develops a topography‐regulated screening platform (12 gradients in 96‐topography‐well plate) enabling analysis of skeletal muscle morphogenesis. The topography‐induced cell morphology changed, cell polarization, and myotube differentiation, establishing an evaluative framework for generating pathologically relevant myotube phenotypes to ...
Tianqi Feng, Torben A.B. van der Boon, Savannah Amy Haupt, Adam Jones, Yanjing Ji, Theo G. Van Kooten, Patrick van Rijn   +6 more
wiley   +1 more source