Results 101 to 110 of about 8,436,957 (350)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Patients’ perspectives about sharing information with providers on social needs during pregnancy: a qualitative study

BMC Health Services Research
Background There is increasing interest in addressing adverse social determinants of health (SDoH) as a part of clinical care, yet there is limited understanding about the perspectives of patients, including pregnant and postpartum individuals from ...
Ramona G. Olvera, Halia Melnyk, Sarah R. MacEwan, Nikki Thomas, Leah Roth, Mireille Bitangacha, Laura J. Rush, Kaprea F. Johnson, William A. Grobman, Ann Scheck McAlearney   +9 more
doaj   +1 more source

Lean towards learning: connecting Lean Thinking and human resource management in UK higher education [PDF]

, 2014
From its origins in the automotive industry, Lean Thinking is increasingly being seen as a solution to problems of efficiency and quality in other industries and sectors. In recent years attempts have been made to transfer Lean principles and practice to
Dankbaar B., Emiliani M. L., Emma Thirkell, Hines P., Ian Ashman, Ichniowski C., Krafcik J., Price J., Radnor Z., Radnor Z., Tracey M., Tracey M.   +11 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Implementasi Berpikir Historis dalam Pembelajaran Sejarah di SMA Negeri 8 dan SMA Negeri 10 Samarinda

Fajar Historia: Jurnal Ilmu Sejarah dan Pendidikan
Historical thinking is a competency that students must master in history learning. This study focuses on the first competency, diachronic (chronological) thinking.
Muhammad Ilham Syahputra, Hieronymus Purwanta, Djono   +2 more
doaj   +1 more source

Critical Thinking in Business Education: Current Outlook and Future Prospects [PDF]

This study investigates all available literature related to critical thinking in business education in a survey of publications in the field produced from 1990-2019.
Calma, Angelito, Davies, W. Martin
core  

Introducing and expanding a futures focus in science classroom [PDF]

, 2010
The article discusses the incorporation of futures thinking in science education programmes in New Zealand. The flexibility of exploring components of the futures thinking model allows for the selection of activities to engage and motivate students.
Buntting, Catherine Michelle
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Physical and Psychosocial Benefits of Sports Participation Among Children and Adolescents with Chronic Diseases: A Systematic Review

Sports Medicine - Open
Background This study aims to identify sports interventions for children and adolescents (CaA) with chronic diseases and evaluate their impact on physical, psychological, and social well-being.
Borja Sañudo, Antonio Jesús Sánchez-Oliver, Jesús Fernández-Gavira, Dominik Gaser, Nicola Stöcker, Miguel Peralta, Adilson Marques, Sofia Papakonstantinou, Chiara Nicolini, Christina Sitzberger   +9 more
doaj   +1 more source