Results 81 to 90 of about 8,436,957 (350)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Ordered Kernels of OBCI-Algebras in the Homomorphism Environment

Mathematics
Yang, Roh and Jun recently introduced kernels of homomorphisms in OBCI-algebras and left an ordered generalization of those kernels as a future work.
Eunsuk Yang, Eun-Hwan Roh, Young-Bae Jun
doaj   +1 more source

Spirituality as a Process within the School Curriculum. [PDF]

, 2003
Spiritual education concerns the quality of our thinking about ourselves, our relationships, our sense of worth and identity, and our sense of well-being. All curriculum subjects can contribute to this search for meaning. Religious education and the act
Bigger, Stephen
core   +1 more source

Educating for Intellectual Virtue: a critique from action guidance [PDF]

, 2019
Virtue epistemology is among the dominant influences in mainstream epistemology today. An important commitment of one strand of virtue epistemology – responsibilist virtue epistemology (e.g., Montmarquet 1993; Zagzebski 1996; Battaly 2006; Baehr 2011 ...
Carter, J. Adam, Kotzee, Ben, Siegel, Harvey   +2 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mathematics [PDF]

, 2008
This chapter discusses mathematics. It is part of a collection which examines educational practice and professional thinking from pre-school and primary, through secondary, further and higher education; and locates Scottish education within its social ...
Maclellan, Effie
core  

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Model of Problem-Based Learning in Geography: Focusing on Societal Dynamics to Enhance Spatial Thinking Skills [PDF]

E3S Web of Conferences
This article explores how problem-based learning (PBL) can enhance geography education by improving spatial thinking through social dynamics. Spatial thinking is crucial for understanding geography’s social complexity and advancing STEM education quality.
Fadjarajani Siti, As’ari Ruli, Putri Anita Eka   +2 more
doaj   +1 more source

Measuring Teaching Staff Members Trends in Sport Education College in university of Mosul towards Criticizing Thinking [PDF]

مجلة الرافدين للعلوم الرياضية, 2007
The study aims at: 1. Designing a tool for measuring trends towards criticizing thinking for teaching staff members at the College of Sport Education in university of Mosul. 2. Identifying nature of teaching staff members’ trends at the College of Sport
Nibras Mohammed Al Murad
doaj   +1 more source