Results 81 to 90 of about 402,332 (352)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Ordered Kernels of OBCI-Algebras in the Homomorphism Environment

Mathematics
Yang, Roh and Jun recently introduced kernels of homomorphisms in OBCI-algebras and left an ordered generalization of those kernels as a future work.
Eunsuk Yang, Eun-Hwan Roh, Young-Bae Jun
doaj   +1 more source

Thinking About Political Education in Formal Education

Revista Electrónica Educare, 2018
The purpose of this essay is to share the reflections about the meaning of politics to be able to think, from there, of the potential of a kind of education capable of giving back to the subject the right to take the floor and act, to exercise the ...
Ana Corina Fernández Alatorre
doaj   +1 more source

Advances in Computational thinking and robotics in education

Eighth International Conference on Technological Ecosystems for Enhancing Multiculturality, 2020
After the computational thinking sessions in the previous 2016-2019 editions of TEEM Conference, the fifth edition of this track has been organized in the current 2020 edition. Computational thinking is still a very significant topic, especially, but not only, in pre-university education.
García-Peñalvo, Francisco José, Conde, Miguel Ángel, Gonçalves, José, Lima, José   +3 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Rethinking sport teaching in physical education: A case study of research based innovation in teacher education

, 2012
This paper focuses on the significance of physical education teacher education (PETE) in the diffusion of 'new' thinking about sport teaching in physical education.
Pill, Shane, Penney, Dawn, Swabey, Karen, Shane Pill, Karen Swabey, Dawn Penney   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Development of Attitude through Critical Thinking

, 2017
No doubt, across the world, advantages of critical thinking in education motivated educators focus on developing the critical thinking ability and traits among students more than ever before, yet ample evidence from literature has shown the lack of ...
Qaisar, Shehzad, Rashid, Sumaira
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Physicians’ experiences screening for and addressing patients’ social needs in prenatal healthcare

Pregnancy
Introduction Addressing social needs that arise from adverse social determinants of health during the prenatal period is a growing priority to help mitigate disparities in maternal and infant health outcomes.
Sarah R. MacEwan, Leah M. Roth, Mireille Bitangacha, Halia Melnyk, Ramona G. Olvera, Nicole Thomas, Laura J. Rush, Kaprea F. Johnson, William Grobman, Ann Scheck McAlearney   +9 more
doaj   +1 more source