Results 141 to 150 of about 3,024,368 (359)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Effect of Problem Based Learning Model Assisted with Poster Media on Students’ Critical Thinking Skills

Thinking Skills and Creativity Journal
The lack of analytical proficiency among elementary school students is evident from their insufficient training in answering contextual questions that require analysis. Consequently, their ability to critically evaluate their work is quite limited. This
Lutfiahtulzanah, Mayarni
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Effectiveness of Contextual Problem Based Learning Model and Personality Types on Students History Learning Outcomes

Thinking Skills and Creativity Journal
Learning outcomes are one of the important factors that used to measure persons success in learning. This study aims to analyze the effectiveness of contextual problem-based history learning models and personality types on student history learning ...
Megiridha Loppies, Kulyasin, Pamela Ayesma   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Developing Critical Thinking Skills for Effective Communication : Citizenship Education and an Experimental English Lesson [PDF]

, 2009
Promoting critical thinking skills is one of several important learning skills necessary for effective communication in English. These abilities are crucial in developing the students' wider views of the world, working with others, and finding out better
KATO, Yuko
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Analytical and critical thinking skills in public relations

, 2014
This article presents more or less independent reasons why analytical and critical thinking skills should be essential part of public relations. Generally, it is considered that the analytical and critical thinking skills are part of public relations, as
Dalibor Jakus, Krešimir Zubčić
core   +1 more source

Teams Games Tournament Learning Model to Improve Elementary School Students' Mathematical Creative Thinking Skills

Thinking Skills and Creativity Journal
The mathematical creative thinking skills of students are still relatively low and need to be improved. Thus, they need a learning model that can enhance their mathematical creative thinking skills.
Ni Made Puspita Udiani, Gusti Ngurah Sastra Agustika, Maria Goreti Rini Kristiantari   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Theory and practice in critical thinking A level and the evacuation of knowledge thesis

, 2012
The concept of critical thinking has been influential in curriculum policy and practice across sectors of UK education and has been identified as a key consideration in recent consultations about A level reform.
Howarth, Mark
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