Results 151 to 160 of about 3,024,368 (359)

Improving Decision-Making Skills in Elementary Schools with Cognitive Flexibility Learning Media Incorporating Balinese Local Wisdom

open access: yesThinking Skills and Creativity Journal
This research is motivated by the low decision-making ability of elementary school students, the limited knowledge of Balinese local wisdom, the suboptimal learning models used, and the insufficient utilization of instructional media.
I Ketut Satria Ardana   +1 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Enhancing fluent and flexible thinking through the creative drama process

open access: yes, 2009
The purpose of this study is to examine whether flexible and fluent thinking skills, two important elements in divergent thinking, can be enhanced through creative drama process.
Karakelle, Sema
core   +1 more source

Scientific Literacy-Oriented Problem Based Learning Model on Improving Critical Thinking Skills

open access: yesThinking Skills and Creativity Journal
This research was motivated by the difficulty of the buffer solution material and students' critical thinking skills which were still relatively low. Aim of this research is to analyze the effect of implementing a scientific literacy-oriented PBL model ...
Faridatul Auliya, Muchlis
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Academic Writing(A) : Logical Thinking Skills In Academic Writing [PDF]

open access: yes, 2014
The two-semester graduate course has been developed since 2008 based on a new teaching method that integrates the training of logical thinking skills into the training of academic writing.
ライ・ウェイリン, ポール
core  

A guide for mastering critical thinking skills

open access: yes, 2023
Critical thinking skills are a cornerstone of intellectual empowerment and adaptability in today's complex and dynamic world. The ability to think critically enables individuals to navigate a sea of information, analyze complex problems, and make ...
Khalifa, Othman Omran
core  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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