Results 11 to 20 of about 19,621 (184)

Pretreatment of trans-ferulic acid improved neurotoxicity in a thioacetamide-induced hepatic encephalopathy rat model; participation of the MAPK/NF-κb signaling pathway [PDF]

Frontiers in Pharmacology
AimTrans-ferulic acid (TFA), a naturally occurring phenolic compound, has attracted significant attention due to its strong hepatoprotective and neuroprotective properties.
Adil Furkan Kilic, Bahadir Suleyman, Renad Mammadov, Seval Bulut, Ali Sefa Mendil, Halis Suleyman   +5 more
doaj   +2 more sources

Good Manufacturing Practice-Derived Human Liver Stem Cell Extracellular Vesicles Attenuate Liver Fibrosis In Vivo [PDF]

Cells
Human liver stem cells (HLSCs) are a mesenchymal stromal cell (MSC)-like population isolated from adult liver biopsies. HLSCs share key characteristics with MSCs, including phenotype and differentiation capabilities.
Elena Ceccotti, Veronica Dimuccio, Chiara Pasquino, Massimo Cedrino, Maria Beatriz Herrera Sanchez, Cristina Grange, Federico Figliolini, Giorgio Nicolò, Federica Antico, Selene Limoncelli, Giulio Mengozzi, Giulia Gioiello, Marta Tapparo, Fabio Cattelino, Renato Romagnoli, Giovanni Camussi, Valentina Fonsato, Stefania Bruno   +17 more
doaj   +2 more sources

Mass Cytometry Study on Hepatic Fibrosis and Its Drug-Induced Recovery Using Mouse Peripheral Blood Mononuclear Cells

Frontiers in Immunology, 2022
The number of patients with liver diseases has increased significantly with the progress of global industrialization. Hepatic fibrosis, one of the most common liver diseases diagnosed in many developed countries, occurs in response to chronic liver ...
Jiwon Bae, Ji Eun Kim, Haribalan Perumalsamy, Sehee Park, Yun Kim, Yun Kim, Dae Won Jun, Dae Won Jun, Dae Won Jun, Tae Hyun Yoon, Tae Hyun Yoon, Tae Hyun Yoon, Tae Hyun Yoon   +12 more
doaj   +1 more source

The Protective Effect of Quercetin on Thioacetamide- Induced Liver Cirrhosis in Adult Male Albino Rats [PDF]

The Egyptian Journal of Histology, 2023
Introduction: Liver Cirrhosis is a major health problem affecting many people worldwide. To date, no efficient treatment approach has developed for this disease.Objectives: The current study was conducted to evaluate the potential of quercetin (QR) to ...
Aliaa El-Alkamy, Shawky Tayel, Maha Safwat, Dina Abdallah, Nehal Nabil   +4 more
doaj   +1 more source

A Modular Synthesis of C5‐Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry

Angewandte Chemie, EarlyView.
Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy, Theo C. Webb, Barnaby W. Greenland, S. Mark Roe, John Spencer, Storm Hassell‐Hart   +5 more
wiley   +2 more sources

Regenerative Effect of Bone Marrow-derived Mesenchymal Stem Cells in Thioacetamide-induced Liver Fibrosis of Rats [PDF]

Archives of Razi Institute, 2019
The present study determined the regenerative effect of bone marrow-derived stem cells (BMSCs) on thioacetamide (TA)-induced liver fibrosis in rats. A total of 30 male Wistar rats were randomly divided into sham control and treatment groups.
D. Mehrabani, Z. Khajehahmadi, P Tajik, A. Tamadon, F. Rahmanifar, M. Ashraf, N. Tanideh, S. Zare   +7 more
doaj   +1 more source

Investigating the Effects of Ellagic Acid on Thioacetamide-Induced Acute Liver Damage and Subsequent Encephalopathy in Rats [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Ellagic acid is a natural polyphenol compound with potential antioxidant properties that is present in most fruits, seeds, and vegetables.
Afarin Joudaki nezhad, Hamidreza Mohammadi, Farhad Momeni, Morteza Amraei, Ahmad Adineh   +4 more
doaj  

Gardeniae Fructus Attenuates Thioacetamide-Induced Liver Fibrosis in Mice via Both AMPK/SIRT1/NF-κB Pathway and Nrf2 Signaling

Antioxidants, 2021
Liver fibrosis, which means a sort of the excessive accumulation of extracellular matrices (ECMs) components through the liver tissue, is considered as tissue repair or wound-healing status.
Mi-Rae Shin, Jin A Lee, Minju Kim, Sehui Lee, Minhyuck Oh, Jimin Moon, Joo-Won Nam, Hyukjae Choi, Yeun-Ja Mun, Seong-Soo Roh   +9 more
doaj   +1 more source

Effect of dihydromyricetin on hepatic encephalopathy associated with acute hepatic failure in mice

Pharmaceutical Biology, 2021
Context Hepatic encephalopathy (HE) is a complex neuropsychiatric disease caused by liver failure. Dihydromyricetin (DMY) is a traditional medicine used to treat liver injury.
Long Cheng, Xiaoying Wang, Xueni Ma, Huimei Xu, Yifan Yang, Dekui Zhang   +5 more
doaj   +1 more source

Evaluation of the Effect of Wheat Germ Oil and Olmutinib on the Thioacetamide-Induced Liver and Kidney Toxicity in Mice

Life, 2022
Thioacetamide (TAA) intoxication produces a reproducible standard animal model of induced liver and kidney injuries where free radicals are produced by phase I oxidation reactions, which eventually leads to liver and kidney failure.
Salman Alamery, Seema Zargar, Fatimah Yaseen, Tanveer A. Wani, Abdulaziz Siyal   +4 more
doaj   +1 more source