Results 161 to 170 of about 10,117 (217)

Fluorometric Assay of Thioguanine

Journal of Pharmaceutical Sciences, 1975
A spectrophotofluorometric method is described for the assay of thioguanine. The assay involves the oxidation of thioguanine with potassium permanganate to a fluorescent product. The method is suitable for routine quality control in laboratory preparations of thioguanine.
exaly   +3 more sources

Microbial metabolism of thiopurines: A method to measure thioguanine nucleotides

Journal of Microbiological Methods, 2016
Thiopurines are anti-inflammatory prodrugs. We hypothesised that bacteria may contribute to conversion to active drug. Escherichia coli strain DH5α was evaluated to determine whether it could metabolise the thiopurine drugs, thioguanine or mercaptopurine,
Iulia Oancea, Páraic O Cuív, Ramya Movva   +2 more
exaly   +2 more sources

Deoxythioguanosine and thioguanine

Clinical Pharmacology & Therapeutics, 1973
Incorporation of 6‐thioguanine (TG) and β‐2'‐deoxythioguanosine (β‐TGdR) into the DNA and RNA of human bone marrow and tumors were measured. The ratio of incorporation into DNA vs that into RNA was taken as an indication of the extent to which β‐TGdR was a direct precursor for DNA synthesis without conversion to TG.
G A, LePage, J A, Gottlieb
openaire   +2 more sources

Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial

Lancet, The, 2006
BACKGROUND: 6-mercaptopurine has been a standard component of long-term continuing treatment for childhood lymphoblastic leukaemia, whereas 6-thioguanine has been mainly used for intensification courses.
Ajay Vora, Lynne Lennard
exaly   +2 more sources

The actions of thioguanine in Bacillus cereus

Biochemical Pharmacology, 1965
Abstract The effects of the guanine analog, 6-thioguanine, have been evaluated in exponentially growing cultures of Bacillus cereus . The drug produced growth inhibition instantly, the duration but not the degree of which was related to the inhibitor concentration.
H G, Mandel, R G, Latimer, M, Riis
openaire   +2 more sources

Absence of nodular regenerative hyperplasia after low-dose 6-thioguanine maintenance therapy in inflammatory bowel disease patients

Digestive and Liver Disease, 2008
BACKGROUND: The use of 6-thioguanine has been proposed as a rescue drug for inflammatory bowel disease patients. Initial data on short-term efficacy and toxicity of 6-thioguanine were promising; however, these have been challenged by reports concerning ...
Elisabeth Bloemena, Ad van Bodegraven, C J J Mulder   +2 more
exaly   +2 more sources

TREATMENT OF PSORIASIS WITH 6‐THIOGUANINE

Australasian Journal of Dermatology, 1988
SummaryFifty‐four patients with Psoriasis were treated with the antimetabolite, 6‐thioguanine (TG). Three were early drop‐outs due to side effects. Of 48 evaluable patients with plaque‐type lesions, mostly extensive, 79% achieved over 75% improvement as an initial response, 8% had over 50% improvement and 13% had less than 50% improvement. 65% retained
H S, Zackheim, H I, Maibach
openaire   +2 more sources

Encapsulation of thioguanine in liposomes

International Journal of Pharmaceutics, 1995
Abstract Thioguanine, a chemotherapeutic drug employed in the treatment of leukemia, was encapsulated in three kinds of liposomes: extrusion, ethanol injection and dehydration-rehydration vesicles. The degree of entrapment was examined at three different concentrations, 1, 0.1 and 0.01 mM, and three pH values, 4.7, 7.4 and 9.2.
Mercè Foradada, Joan Estelrich
openaire   +1 more source

6-Thioguanine Metabolism in Human Erythrocytes

1991
Thiopurines must undergo enzymatic conversion into a variety of nucleotide derivatives in order to display cytotoxic activity [1]; the major ones in human erythrocytes are the 6-thioguanine nucleotides [2]. These compounds derive from the immunosuppressive agent azathioprine as well as from the cytotoxic drugs 6-thioguanine and 6-mercaptopurine [3 ...
A. Lucano, C. Crifo, SALERNO, Costantino
openaire   +3 more sources