Results 131 to 140 of about 427,077 (192)

Periodontal Health and Salivary Thiol-Disulphide Homeostasis in Multiple Sclerosis Patients

Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi
Objective: Multiple sclerosis (MS) is a chronic autoimmune disease in which neuroinflammation and oxidative stress play important roles in its pathology.
Fatma Yeşim Kırzıoğlu, Serpil Demirci, Çağla Varol, Melike Doğan Ünlü, Mustafa Calapoğlu, Hikmet Orhan   +5 more
doaj   +1 more source

Glutamine Metabolism in Health and Diseases

MedComm, Volume 7, Issue 10, October 2026.
Glutamine metabolism acts as a metabolic hub connecting cellular stress adaptation, immune regulation, and disease development. Through regulating energy production, biosynthesis, redox balance, and nitrogen metabolism, glutamine supports cellular homeostasis under physiological and pathological conditions.
Yi Ding, Fan Tong, Jing Zeng, Chun‐Ping Cui   +3 more
wiley   +1 more source

Beta Cell Stress to Epitope Diversification: Post‐Translationally Modified Antigens in Type 1 Diabetes

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Pancreatic beta cells are active participants in the loss of immune tolerance because their high secretory demand creates exceptional vulnerability to inflammatory exposure, endoplasmic reticulum (ER) stress, calcium dysregulation, and redox imbalance. These conditions can promote enzymatic and nonenzymatic changes in self‐proteins, generating
Megan L. Proffer, Saptarshi Roy, Jon D. Piganelli   +2 more
wiley   +1 more source

Beyond the Active Site: First‐In‐Class Leishmania Infantum Trypanothione Reductase Dimerization Disruptors as Antileishmanial Leads

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
This review outlines a pioneering strategy to inhibit Leishmania infantum trypanothione reductase by disrupting its dimer interface. From peptides to small‐molecule proteomimetics, multiple chemotypes achieved potent enzymatic inhibition and notable cellular antileishmanial activity, highlighting a new therapeutic paradigm.
María‐José Camarasa, Miguel Maldonado, Alvaro de la Cruz‐Potenciano, Sonia de Castro   +3 more
wiley   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

The effects of dexmedetomidine on thiol/disulphide homeostasis in coronary artery bypass surgery: a randomized controlled trial

BMC Anesthesiology
Background Thiol-disulfide homeostasis (TDH) plays a pivotal role in various physiological mechanisms, including antioxidant defence, detoxification, apoptosis, regulation of enzyme activities and cellular signal transduction.
Yusuf Ozguner, Savaş Altınsoy, Gökçen Kültüroğlu, Dilek Unal, Julide Ergil, Salim Neşelioğlu, Özcan Erel   +6 more
doaj   +1 more source

Altered Thiol-Disulfide Homeostasis in Sarcoidosis: A Case-Control Study. [PDF]

Medicina (Kaunas)
Uzdogan EA, Kocaer ZH, Neselioglu S, Karalezli A, Erel O.   +4 more
europepmc   +1 more source

Thiol-Disulfide Homeostasis and Erythrocyte Glutathione Balance in ST-Elevation Myocardial Infarction: A Prospective Case-Control Study. [PDF]

J Cardiovasc Dev Dis
Danış F, Alışık M.
europepmc   +1 more source

Effect of mode of delivery on neonatal oxidative stress and dynamic thiol-disulfide homeostasis. [PDF]

J Int Med Res, 2023
Genc SO, Erdal H.
europepmc   +1 more source

Short-Term Alterations in Thiol-Disulfide Homeostasis Following ERCP: A Prospective Controlled Study. [PDF]

Dig Dis Sci
Asıl M, Avcı Y, Erdem AC, Dertli R, Bıyık M, Keskin M, Erel Ö, Neşelioğlu S.   +7 more
europepmc   +1 more source