Results 1 to 10 of about 281,561 (238)

Bidirectional Disulfide Metathesis Enables Recycling of High-Performance Thermoset Networks. [PDF]

Adv Sci (Weinh)
A cyclic aromatic disulfide comonomer enables dual‐mode recyclable pDCPD thermosets through bidirectional disulfide metathesis. The resulting networks combine enhanced mechanical performance with thermal reprocessability and chemical depolymerization into reusable oligomeric fragments, allowing regeneration of high‐performance thermosets with minimal ...
Li B, Zheng J, Situmorang DP, Neo JX, Feng H, Li J, Xian-Jun L, Li Z, Loh TP.   +8 more
europepmc   +2 more sources

Albumin–Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells

Pharmaceutics, 2021
A family of monomodified bovine serum albumin (BSA) linked to methotrexate (MTX) through a variety of spacers was prepared. All analogues were found to be prodrugs having low MTX-inhibitory potencies toward dihydrofolate reductase in a cell-free system ...
Itzik Cooper, Michal Schnaider-Beeri, Mati Fridkin, Yoram Shechter   +3 more
doaj   +1 more source

Thiol/disulfide homeostasis in gastritis with or without Helicobacter pylori

International Journal of Medical Biochemistry, 2022
INTRODUCTION: In this study, it was aimed to evaluate how thiol/disulfide homeostasis is affected in Helicobacter pylori positive and negative gastritis and the efficiency of thiol/disulfide levels in the diagnosis of chronic gastritis. METHODS: Seventy
Yakup Dulgeroglu, Osman Bandirmali
doaj   +1 more source

Beyond Traditional Phenolics: Disulfide Bonds for Performance Enhancement of Aerospace Ablation-Resistant Materials from Processing to Recycling. [PDF]

Adv Sci (Weinh)
The dynamic disulfide bonds facilitated the development of high‐performance aerospace ablation‐resistant materials. At moderate temperature, the dissociation and recombination of disulfide bonds ensured excellent processability, mechanical properties, and recycling ability of phenolic resin; at high temperature, cleavage of disulfide bonds produced ...
Li Y, Hu B, Xing X, Yang H, Zhang Z, Bian C, Bai R, Yue L, Zhang C, Jing X.   +9 more
europepmc   +2 more sources

Ischemia modified albumin level and thiol/disulfide homeostasis in the etiology of tinnitus

International Journal of Medical Biochemistry, 2022
INTRODUCTION: Although many theories about the etiology of tinnitus have been proposed, it has not been fully clarified. In this study, we investigated the role of ischemia in the etiology of tinnitus.
Hüseyin Kurku, Mehmet Akif Bor, Mustafa Faris Tulgar, Salim Neselioglu, Necat Alatas   +4 more
doaj   +1 more source

A Disulfide-Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self-Assembly Mechanism to Functional Application in Hair Regeneration. [PDF]

Adv Sci (Weinh)
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Wang L, Yang J, Jiang X, Zheng Z, Wei H, Li N, Chu X, Liu W.   +7 more
europepmc   +2 more sources

Redox-Responsive Comparison of Diselenide and Disulfide Core-Cross-Linked Micelles for Drug Delivery Application

Pharmaceutics, 2023
In this study, diselenide (Se–Se) and disulfide (S–S) redox-responsive core-cross-linked (CCL) micelles were synthesized using poly(ethylene oxide)2k-b-poly(furfuryl methacrylate)1.5k (PEO2k-b-PFMA1.5k), and their redox sensitivity was compared. A single
Sonyabapu Yadav, Kalyan Ramesh, Obireddy Sreekanth Reddy, Viswanathan Karthika, Parveen Kumar, Sung-Han Jo, Seong II Yoo, Sang-Hyug Park, Kwon Taek Lim   +8 more
doaj   +1 more source

α-Conotoxin Peptidomimetics: Probing the Minimal Binding Motif for Effective Analgesia

Toxins, 2020
Several analgesic α-conotoxins have been isolated from marine cone snails. Structural modification of native peptides has provided potent and selective analogues for two of its known biological targets—nicotinic acetylcholine and γ-aminobutyric acid ...
Adam C. Kennedy, Alessia Belgi, Benjamin W. Husselbee, David Spanswick, Raymond S. Norton, Andrea J. Robinson   +5 more
doaj   +1 more source

A native chemical chaperone in the human eye lens

eLife, 2022
Cataract is one of the most prevalent protein aggregation disorders and still the most common cause of vision loss worldwide. The metabolically quiescent core region of the human lens lacks cellular or protein turnover; it has therefore evolved ...
Eugene Serebryany, Sourav Chowdhury, Christopher N Woods, David C Thorn, Nicki E Watson, Arthur A McClelland, Rachel E Klevit, Eugene I Shakhnovich   +7 more
doaj   +1 more source

Assigning function to active site residues of Schistosoma mansoni thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme

Frontiers in Molecular Biosciences, 2023
Thioredoxin/glutathione reductase (TGR) from the platyhelminthic parasitic worms has recently been identified as a drug target for the treatment of schistosomiasis.
Madison M. Smith, Graham R. Moran
doaj   +1 more source