Results 1 to 10 of about 310,956 (218)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer. [PDF]

Mol Oncol
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Abad L, Tosatto SCE, Leonardi E.
europepmc   +2 more sources

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

BMC Biology, 2021
Background The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau folding pathways that ...
Sang-Gyun Kang, Zhuang Zhuang Han, Nathalie Daude, Emily McNamara, Serene Wohlgemuth, Laura Molina-Porcel, Jiri G. Safar, Sue-Ann Mok, David Westaway   +8 more
doaj   +1 more source

Innate Immune Status of Glia Modulates Prion Propagation in Early Stage of Infection

Cells, 2023
Prion diseases are progressive neurodegenerative disorders affecting humans and various mammals. The prominent neuropathological change in prion-affected brains is neuroinflammation, histopathologically characterized by reactive gliosis surrounding prion
Sang-Gyun Kang, Chiye Kim, Judd Aiken, Debbie McKenzie   +3 more
doaj   +1 more source

Reorganization of Cell Compartmentalization Induced by Stress

Biomolecules, 2022
The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization.
Anna S. Fefilova, Iuliia A. Antifeeva, Anastasia A. Gavrilova, Konstantin K. Turoverov, Irina M. Kuznetsova, Alexander V. Fonin   +5 more
doaj   +1 more source

The measurement of true initial rates is not always absolutely necessary to estimate enzyme kinetic parameters

Scientific Reports, 2023
In the chapters dealing with enzyme reactions, the authors of all Biochemistry textbooks and of even more specialized texts consider that the characteristic parameters (k cat and K m ) must be determined under initial or steady-state rate conditions ...
Jean-Marie Frère, Olivier Verlaine, André Matagne   +2 more
doaj   +1 more source

Unconjugated PLGA nanoparticles attenuate temperature-dependent β-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer’s disease pathology

Journal of Nanobiotechnology, 2022
Conversion of β-amyloid (Aβ) peptides from soluble random-coil to aggregated protein enriched with β-sheet-rich intermediates has been suggested to play a role in the degeneration of neurons and development of Alzheimer’s disease (AD) pathology ...
Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Mariana Kulka, Satyabrata Kar   +7 more
doaj   +1 more source

Susceptibility of Beavers to Chronic Wasting Disease

Biology, 2022
Chronic wasting disease (CWD) is a contagious, fatal, neurodegenerative prion disease of cervids. The expanding geographical range and rising prevalence of CWD are increasing the risk of pathogen transfer and spillover of CWD to non-cervid sympatric ...
Allen Herbst, Serene Wohlgemuth, Jing Yang, Andrew R. Castle, Diana Martinez Moreno, Alicia Otero, Judd M. Aiken, David Westaway, Debbie McKenzie   +8 more
doaj   +1 more source

Prion-Like Propagation Mechanisms in Tauopathies and Traumatic Brain Injury: Challenges and Prospects

Biomolecules, 2020
The accumulation of tau protein in the form of filamentous aggregates is a hallmark of many neurodegenerative diseases such as Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE).
Hadeel Alyenbaawi, W. Ted Allison, Sue-Ann Mok   +2 more
doaj   +1 more source

The Standard Scrapie Cell Assay: Development, Utility and Prospects

Viruses, 2015
Prion diseases are a family of fatal neurodegenerative diseases that involve the misfolding of a host protein, PrPC. Measuring prion infectivity is necessary for determining efficacy of a treatment or infectivity of a prion purification procedure; animal
Jacques van der Merwe, Judd Aiken, David Westaway, Debbie McKenzie   +3 more
doaj   +1 more source

Structure and stability of recombinant bovine odorant-binding protein: II. Unfolding of the monomeric forms [PDF]

PeerJ, 2016
In a family of monomeric odorant-binding proteins (OBPs), bovine OBP (bOBP), that lacks conserved disulfide bond found in other OBPs, occupies unique niche because of its ability to form domain-swapped dimers.
Olga V. Stepanenko, Denis O. Roginskii, Olesya V. Stepanenko, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov   +5 more
doaj   +2 more sources