Results 21 to 30 of about 391,837 (318)
Fold recognition without folds [PDF]
Protein Science, 2002 AbstractFold recognition predicts protein three‐dimensional structure by establishing relationships between a protein sequence and known protein structures. Most methods explicitly use information derived from the secondary and tertiary structure of the templates.
Koretke, K. +2 more
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Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation
EMBO Molecular Medicine, 2015 The cellular prion protein (PrPC) comprises a natively unstructured N‐terminal domain, including a metal‐binding octarepeat region (OR) and a linker, followed by a C‐terminal domain that misfolds to form PrPSc in Creutzfeldt‐Jakob disease.
Agnes Lau +19 more
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The unfolding of iRFP713 in a crowded milieu [PDF]
PeerJ, 2019 The exploring of biological processes in vitro under conditions of macromolecular crowding is a way to achieve an understanding of how these processes occur in vivo.
Olesya V. Stepanenko +3 more
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Amyloid fibrils degradation: the pathway to recovery or aggravation of the disease?
Frontiers in Molecular Biosciences, 2023 Background: The most obvious manifestation of amyloidoses is the accumulation of amyloid fibrils as plaques in tissues and organs, which always leads to a noticeable deterioration in the patients’ condition and is the main marker of the disease. For this
Maksim I. Sulatsky +6 more
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Acta Naturae, 2021 Understanding the nature of the forces driving the folding of proteins, nucleic acids and the formation of their complexes absolutely requires thermodynamic data, in addition to structural information. In practical terms, this means the use of super-sensitive scanning and titration calorimeters for experimental determination of the heats (enthalpies ...
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Properties of the free energy barriers for folding of the [alpha]-amylase inhibitor tendamistat [PDF]
, 2005 The goal of this work was to improve our understanding of the properties of the free energy barriers in protein folding. We used the small all-[beta]-sheet protein tendamistat as a model protein. Tendamistat contains two disulfide bridges and folds and
Schätzle, Manuela
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Scientific Reports, 2021 In light of legislative changes and the widespread use of cannabis as a recreational and medicinal drug, delayed effects of cannabis upon brief exposure during embryonic development are of high interest as early pregnancies often go undetected.
Richard Kanyo +6 more
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Protein folding on the ribosome studied using NMR spectroscopy [PDF]
, 2013 NMR spectroscopy is a powerful tool for the investigation of protein folding and misfolding, providing a characterization of molecular structure, dynamics and exchange processes, across a very wide range of timescales and with near atomic resolution.
Christodoulou, J +9 more
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Journal of Combinatorial Theory, Series B, 2006 We define folding of a directed graph as a coloring (or a homomorphism) which is injective on all the down sets of a given depth. While in general foldings are as complicated as homomorphisms for some some classes they present an useful tool to study colorings and homomorphisms.
Jaroslav Nesetril +1 more
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Protein folds and protein folding [PDF]
Protein Engineering Design and Selection, 2010 The classification of protein folds is necessarily based on the structural elements that distinguish domains. Classification of protein domains consists of two problems: the partition of structures into domains and the classification of domains into sets of similar structures (or folds).
R Dustin, Schaeffer, Valerie, Daggett
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