Results 11 to 20 of about 391,837 (318)
Structure and stability of recombinant bovine odorant-binding protein: II. Unfolding of the monomeric forms [PDF]
PeerJ, 2016 In a family of monomeric odorant-binding proteins (OBPs), bovine OBP (bOBP), that lacks conserved disulfide bond found in other OBPs, occupies unique niche because of its ability to form domain-swapped dimers.
Olga V. Stepanenko +5 more
doaj +2 more sources
Biomolecules, 2023 The formation and function of membrane-less organelles (MLOs) is one of the main driving forces in the molecular life of the cell. These processes are based on the separation of biopolymers into phases regulated by multiple specific and nonspecific inter-
Sergey A. Silonov +7 more
doaj +1 more source
The Standard Scrapie Cell Assay: Development, Utility and Prospects
Viruses, 2015 Prion diseases are a family of fatal neurodegenerative diseases that involve the misfolding of a host protein, PrPC. Measuring prion infectivity is necessary for determining efficacy of a treatment or infectivity of a prion purification procedure; animal
Jacques van der Merwe +3 more
doaj +1 more source
Mechanisms of evolutionary optimized complex folding reactions [PDF]
, 2007 The mechanisms and speed limits of evolutionary optimized complex folding reactions were investigated in this study. The two viral model proteins, foldon and SFVP, have evolved under selective pressure for fast and efficient folding and association.
Güthe, Sarah
core +1 more source
Flexible protein folding by ant colony optimization [PDF]
, 2008 Protein structure prediction is one of the most challenging topics in bioinformatics. As the protein structure is found to be closely related to its functions, predicting the folding structure of a protein to judge its functions is meaningful to the ...
Hu, X., Li, Y., Zhang, J.
core +1 more source
Molecular Neurodegeneration, 2017 Background MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes.
Ghazaleh Eskandari-Sedighi +11 more
doaj +1 more source
Structure and stability of recombinant bovine odorant-binding protein: I. Design and analysis of monomeric mutants [PDF]
PeerJ, 2016 Bovine odorant-binding protein (bOBP) differs from other lipocalins by lacking the conserved disulfide bond and for being able to form the domain-swapped dimers.
Olga V. Stepanenko +5 more
doaj +2 more sources
Journal of General Internal Medicine, 2002 On some days, a pair of local goats would walk through the halls of Tintswalo Hospital, and no one would bat an eyelash. In a 200-bed hospital run by 12 doctors in their early twenties, in a hospital where an average of 20 patients died each week from symptoms secondary to “immune compromise” (the doctors don't like to use the word AIDS in their death ...
openaire +2 more sources
Structure and stability of recombinant bovine odorant-binding protein: III. Peculiarities of the wild type bOBP unfolding in crowded milieu [PDF]
PeerJ, 2016 Contrary to the majority of the members of the lipocalin family, which are stable monomers with the specific OBP fold (a β-barrel consisting of a 8-stranded anti-parallel β-sheet followed by a short α-helical segment, a ninth β-strand, and a disordered C-
Olga V. Stepanenko +5 more
doaj +2 more sources
Comparing the folding and misfolding energy landscapes of phosphoglycerate kinase. [PDF]
, 2011 Partitioning of polypeptides between protein folding and amyloid formation is of outstanding pathophysiological importance. Using yeast phosphoglycerate kinase as model, here we identify the features of the energy landscape that decide the fate of the ...
Gottfried Köhler +8 more
core +1 more source