Mieap forms membrane-less organelles involved in cardiolipin metabolism [PDF]
iScienceSummary: Biomolecular condensates (BCs) are formed by proteins with intrinsically disordered regions (IDRs) via liquid-liquid phase separation. Mieap/Spata18, a p53-inducible protein, participates in suppression of colorectal tumors by promoting ...
Naoki Ikari +4 more
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Phase transitions and size scaling of membrane-less organelles. [PDF]
J Cell Biol, 2013 The coordinated growth of cells and their organelles is a fundamental and poorly understood problem, with implications for processes ranging from embryonic development to oncogenesis. Recent experiments have shed light on the cell size–dependent assembly of membrane-less cytoplasmic and nucleoplasmic structures, including ribonucleoprotein (RNP ...
Brangwynne CP.
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On the Roles of the Nuclear Non-Coding RNA-Dependent Membrane-Less Organelles in the Cellular Stress Response. [PDF]
Int J Mol Sci, 2023 At the beginning of the 21st century, it became obvious that radical changes had taken place in the concept of living matter and, in particular, in the concept of the organization of intracellular space. The accumulated data testify to the essential importance of phase transitions of biopolymers (first of all, intrinsically disordered proteins and RNA)
Gavrilova AA +6 more
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Refractile bodies of Eimeria tenella are proteinaceous membrane-less organelles that undergo dynamic changes during infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionRefractile bodies (RB) are large membrane-less organelles (MLO) of unknown function found as a prominent mismatched pair within the sporozoite stages of all species of Eimeria, parasitic coccidian protozoa.MethodsHigh resolution imaging ...
Alana Burrell +7 more
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Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles [PDF]
Frontiers in Molecular Biosciences, 2022 In recent decades, a growing number of biomolecular condensates have been identified in eukaryotic cells. These structures form through phase separation and have been linked to a diverse array of cellular processes.
Emma Lacroix +3 more
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Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles. [PDF]
J Mol Biol, 2018 Membrane-less organelles are cellular structures which arise through the phenomenon of phase separation. This process enables compartmentalization of specific sets of macromolecules (e.g., proteins, nucleic acids), thereby regulating cellular processes by increasing local concentration, and modulating the structure and dynamics of their constituents ...
Mitrea DM +6 more
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C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. [PDF]
Cell, 2016 Expansion of a hexanucleotide repeat GGGGCC (G4C2) in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Transcripts carrying (G4C2) expansions undergo unconventional, non-ATG-dependent translation, generating toxic dipeptide repeat (DPR) proteins thought to contribute to disease.
Lee KH +19 more
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Frontiers in Cell and Developmental Biology, 2022 A major recent advance in cell biology is the mechanistic and kinetic understanding of biogenesis of many membrane-less condensates. As membrane-less condensates and membrane-bound organelles are two major approaches used by the eukaryotic cells to ...
Chuankai Zhou, Chuankai Zhou
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Basic design of artificial membrane-less organelles using condensation-prone proteins in plant cells [PDF]
Communications BiologyMembrane-less organelles, formed by the condensation of biomolecules, play a pivotal role in eukaryotes. Artificial membrane-less organelles and condensates are effective tools for the creation of new cellular functions.
Yoshito Koja +6 more
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Supramolecular Fuzziness of Intracellular Liquid Droplets: Liquid–Liquid Phase Transitions, Membrane-Less Organelles, and Intrinsic Disorder [PDF]
Molecules, 2019 Cells are inhomogeneously crowded, possessing a wide range of intracellular liquid droplets abundantly present in the cytoplasm of eukaryotic and bacterial cells, in the mitochondrial matrix and nucleoplasm of eukaryotes, and in the chloroplast’s ...
Vladimir N. Uversky
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