Results 41 to 50 of about 5,515,438 (264)

Client proximity enhancement inside cellular membrane-less compartments governed by client-compartment interactions

Nature Communications, 2020
Membrane-less organelles or compartments are considered to be dynamic reaction centers for spatiotemporal control of diverse cellular processes. Here authors report quantitative measurements of changes in protein interactions for the proteins recruited ...
Daesun Song, Yongsang Jo, Jeong-Mo Choi, Yongwon Jung   +3 more
doaj   +1 more source

Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis [PDF]

, 2009
The final step during cell division is the separation of daughter cells, a process that requires the coordinated delivery and assembly of new membrane to the cleavage furrow.
Manuel Rauch, Naissant, B., Sabine Thiberge, Langsley, G., Fathia Ben Rached, Ben Rached, F., Meissner, M, Meissner, M., Rauch, M., Angelika Kretzschmar, Agop-Nersesian, C., Kretzschmar, A., David J P Ferguson, Menard, R., Langsley, G, Ferguson, DJP, Ben Rached, F, Ferguson, DJ, Markus Meissner, David J. P. Ferguson, Rauch, M, Carolina Agop-Nersesian, Naissant, B, Agop-Nersesian, C, Robert Menard, Thiberge, S., Kretzschmar, A, Menard, R, Gordon Langsley, Thiberge, S, Ferguson, D.J.P., Bernina Naissant   +31 more
core   +1 more source

Engineering controllable CAR T-cell therapies: from binary safety switches to programmable immunity

Frontiers in Immunology
Chimeric antigen receptor (CAR) T-cell therapy has revolutionised cancer gene therapy, yet its expansion into solid tumours is hindered by a critical vulnerability: the autonomous, “always-on” nature of conventional CAR constructs.
Sergei Smirnov, Sergei Smirnov, Yuriy Zaritskey, Yuriy Zaritskey, Galina Salogub, Alexander Fonin   +5 more
doaj   +1 more source

Protein phase separation: new insights into cell division

Acta Biochimica et Biophysica Sinica, 2023
As the foundation for the development of multicellular organisms and the self-renewal of single cells, cell division is a highly organized event which segregates cellular components into two daughter cells equally or unequally, thus producing daughters ...
Zheng Hongdan, Wen Wenyu
doaj   +1 more source

The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells [PDF]

, 2008
The protein product of the ocular albinism type 1 gene, named OA1, is a pigment cell-specific G protein-coupled receptor exclusively localized to intracellular organelles, namely lysosomes and melanosomes.
Bennett, DC, Venturi C, Palmigiano, A, Schiaffino, MV, Piccirillo, R, Altimare D., Rotondo G., Tacchetti, C, Marigo, V, Bagnato P., Coppola M., Rotondo, G, Venturi, C, Sviderskaya, EV, Palmisano I., Palmigiano A., Altimare D, Bagnato, P, Marigo V., Surace, EM, Altimare, D, Tacchetti C, Innamorati G., Venturi C., Surace E. M., Palmisano I, Rotondo G, INNAMORATI, Giulio, BALLABIO, ANDREA, Schiaffino M. V., Sviderskaya E. V., Palmigiano A, Innamorati G, SURACE, Enrico Maria, Sviderskaya EV, Piccirillo R, Bagnato P, Ballabio A., Incerti B, Piccirillo R., Tacchetti C., Schiaffino MV, Coppola, M, Incerti, B, Bennett DC, Incerti B., Palmisano, I, Coppola M, Bennett D. C., Innamorati, G, Ballabio, A, Marigo V   +51 more
core   +1 more source

Mutual remodeling of interacting nanodroplets and vesicles

Communications Physics, 2023
Biomolecular condensates are membrane-less organelles performing various functions inside cells which behaviour can be understood in terms of liquid-liquid phase separation and wetting. Here, the authors characterize the low interfacial tension regime of
Vahid Satarifard, Reinhard Lipowsky
doaj   +1 more source

Fragment-based discovery of TopBP1 inhibitors integrated with AI-driven molecular docking

Magnetic Resonance Letters
DNA topoisomerase IIβ-binding protein 1 (TopBP1) converges on multiple oncogenic pathways, e.g., Rb, p53, and PI3K/Akt, which are hallmarks of most cancer progression.
Wenlong Chen, Song Zhang, Zihuan Li, Lei Wang, Jiahai Zhang, Jia Gao, Ke Ruan   +6 more
doaj   +1 more source

Emerging Implications of Phase Separation in Cancer

Advanced Science, 2022
In eukaryotic cells, biological activities are executed in distinct cellular compartments or organelles. Canonical organelles with membrane‐bound structures are well understood. Cells also inherently contain versatile membrane‐less organelles (MLOs) that
Jiang Ren, Zhenyu Zhang, Zhi Zong, Long Zhang, Fangfang Zhou   +4 more
doaj   +1 more source

The rise of NMR-integrated fragment-based drug discovery in China

Magnetic Resonance Letters
Nuclear magnetic resonance (NMR) spectroscopy is an indispensable tool to probe weak protein-ligand interactions, which are key to the hit identification and hit-to-lead evolution in fragment-based drug discovery (FBDD). The integration of NMR technology
Zihuan Li, Lei Wang, Jia Gao, Ke Ruan
doaj   +1 more source

Controlled Level of Contamination Coupled to Deep Sequencing (CoLoC-seq) Probes the Global Localisation Topology of Organelle Transcriptomes

Bio-Protocol, 2023
Information on RNA localisation is essential for understanding physiological and pathological processes, such as gene expression, cell reprogramming, host–pathogen interactions, and signalling pathways involving RNA transactions at the level of membrane ...
Anna Smirnova, Damien Jeandard, Alexandre Smirnov   +2 more
doaj   +1 more source