Results 21 to 30 of about 5,515,438 (264)
Nature Communications, 2021 Interorganelle membrane contact sites between the endoplasmic reticulum and mitochondria can be mediated with the ER-mitochondria encounter structure (ERMES) complex, though precise regulation is unclear. Here, the authors report that the number of ERMES
Faiz Rasul +8 more
doaj +1 more source
Cell Reports, 2023 Summary: Huntington’s disease (HD) usually causes cognitive disorders, including learning difficulties, that emerge before motor symptoms. Mutations related to lysosomal trafficking are linked to the pathogenesis of neurological diseases, whereas the ...
Jia-Hui Chen +10 more
doaj +1 more source
Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance
Nature Communications, 2023 E-cadherin is an essential cell‒cell adhesion protein that mediates canonical cadherin-catenin complex formation in epithelial lateral membranes.
Chao Kong +11 more
doaj +1 more source
Assembly status transition offers an avenue for activity modulation of a supramolecular enzyme
eLife, 2021 Nature has evolved many supramolecular proteins assembled in certain, sometimes even seemingly oversophisticated, morphological manners. The rationale behind such evolutionary efforts is often poorly understood.
Yao Chen +8 more
doaj +1 more source
Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex
Cell Reports, 2021 Summary: Stereocilia, the mechanosensory organelles on the apical surface of hair cells, are necessary to detect sound and carry out mechano-electrical transduction.
Lin Lin +6 more
doaj +1 more source
Frontiers in Environmental Chemistry, 2022 The existence of membrane-less organelles in the cells has been known for a relatively long time. Of the membrane-less organelles, stress granules, processing bodies, and PML-NBs have been intensively investigated in relation to arsenic.
Osamu Udagawa, Seishiro Hirano
doaj +1 more source
SUMO: Glue or Solvent for Phase-Separated Ribonucleoprotein Complexes and Molecular Condensates?
Frontiers in Molecular Biosciences, 2021 Spatial organization of cellular processes in membranous or membrane-less organelles (MLOs, alias molecular condensates) is a key concept for compartmentalizing biochemical pathways.
Jan Keiten-Schmitz +5 more
doaj +1 more source
Revealing RCOR2 as a regulatory component of nuclear speckles
Epigenetics & Chromatin, 2021 Background Nuclear processes such as transcription and RNA maturation can be impacted by subnuclear compartmentalization in condensates and nuclear bodies.
Carlos Rivera +8 more
doaj +1 more source
Reorganization of Cell Compartmentalization Induced by Stress
Biomolecules, 2022 The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization.
Anna S. Fefilova +5 more
doaj +1 more source
Phase Separation of Disordered Protein in the Formation of Membrane-Less Organelles [PDF]
Biophysical Journal, 2014 Intrinsically disordered proteins and regions (IDPs/IDRs), which do not have stable secondary and tertiary structure, are capable of adopting different structural states. Many IDPs/IDRs populate conformationally heterogeneous monomeric states or engage in discrete interactions with other proteins, leading to folding upon binding or retaining ...
Nott, T +5 more
openaire +2 more sources