A Systems-Level Study Reveals Regulators of Membrane-less Organelles in Human Cells [PDF]
Molecular Cell, 2018 Membrane-less organelles (MLOs) are liquid-like subcellular compartments that form through phase separation of proteins and RNA. While their biophysical properties are increasingly understood, their regulation and the consequences of perturbed MLO states for cell physiology are less clear. To study the regulatory networks, we targeted 1,354 human genes
Nico Battich, Lucas Pelkmans
exaly +6 more sources
Nucleolar- and Nuclear-Stress-Induced Membrane-Less Organelles: A Proteome Analysis through the Prism of Liquid-Liquid Phase Separation. [PDF]
Int J Mol Sci, 2023 Radical changes in the idea of the organization of intracellular space that occurred in the early 2010s made it possible to consider the formation and functioning of so-called membrane-less organelles (MLOs) based on a single physical principle: the ...
Mokin YI +6 more
europepmc +3 more sources
Abnormal regulation of membrane-less organelles contributes to profilin1-associated ALS. [PDF]
J Biol ChemProfilin 1 (PFN1) is a key cytoskeletal protein that regulates actin dynamics by incorporating monomeric actin into linear filaments. PFN1 deletion or mutations have been linked to numerous neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).
Ma G +9 more
europepmc +3 more sources
Smaug1 membrane-less organelles respond to AMPK and mTOR and affect mitochondrial function [PDF]
Journal of Cell Science, 2022 ABSTRACT Smaug is a conserved translational regulator that binds numerous mRNAs, including nuclear transcripts that encode mitochondrial enzymes. Smaug orthologs form cytosolic membrane-less organelles (MLOs) in several organisms and cell types.
Ana J. Fernández-Alvarez +13 more
openaire +6 more sources
Protein-Polymer Complex Coacervates as Synthetic Membrane-less Organelles [PDF]
, 2020 Columbia Undergraduate Science Journal, Vol 14 (2020): Spring ...
Tjo, Hansen +2 more
core +6 more sources
Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila [PDF]
Developmental Biology, 2017 Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities.
Aguilera-Gomez, Angelica +1 more
core +9 more sources
RNAs, Phase Separation, and Membrane‐Less Organelles: Are Post‐Transcriptional Modifications Modulating Organelle Dynamics? [PDF]
BioEssays, 2018 Membranous organelles allow sub‐compartmentalization of biological processes. However, additional subcellular structures create dynamic reaction spaces without the need for membranes. Such membrane‐less organelles (MLOs) are physiologically relevant and impact development, gene expression regulation, and cellular stress responses.
Aleksej, Drino, Matthias R, Schaefer
openaire +3 more sources
NSCLC cells sustain phase separation of cytoplasmic membrane-less organelles to protect themselves against cisplatin treatment. [PDF]
Acta Pharmacol SinCisplatin is the first platinum compound used for anticancer therapy, including non-small cell lung cancer (NSCLC). However, the clinical efficacy of cisplatin is strongly limited by cisplatin resistance. Hence, illuminating the mechanism of cisplatin resistance will aid in the development of therapeutic strategies that improve the sensitivity of ...
Li NN +7 more
europepmc +4 more sources
Dynamics and functional relevance of ribonucleoproteic membrane-less organelles
, 2020 The LV Annual SAIB Meeting and XIV PABMB ...
Boccaccio, Graciela Lidia
core +3 more sources
Correlative Assembly of Subsynaptic Nanoscale Organizations During Development
Frontiers in Synaptic Neuroscience, 2022 Nanoscale organization of presynaptic proteins determines the sites of transmitter release, and its alignment with assemblies of postsynaptic receptors through nanocolumns is suggested to optimize the efficiency of synaptic transmission.
Shi-Yan Sun +8 more
doaj +1 more source