Results 41 to 50 of about 391,837 (318)

Autocatalytic Folding of the Folding Catalyst FKBP12 [PDF]

Journal of Biological Chemistry, 1996
Prolyl isomerases are folding enzymes and thus have the potential to catalyze their own folding. We show here that the folding of cytosolic FKBP12 (FK 506 binding protein) is an autocatalytic process both for the mature protein and for a fusion protein with an amino-terminal extension of 16 residues.
C, Scholz, T, Zarnt, G, Kern, K, Lang, H, Burtscher, G, Fischer, F X, Schmid   +6 more
openaire   +2 more sources

Dynamics in unfolded polypeptide chains as model for elementary steps in protein folding [PDF]

, 2004
This thesis deals with the dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding. Starting from an ensemble of unfolded conformations a folding polypeptide chain has to form specific backbone and side-chain ...
Krieger, Florian
core   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

eLife, 2021
Traumatic brain injury (TBI) is a prominent risk factor for dementias including tauopathies like chronic traumatic encephalopathy (CTE). The mechanisms that promote prion-like spreading of Tau aggregates after TBI are not fully understood, in part due to
Hadeel Alyenbaawi, Richard Kanyo, Laszlo F Locskai, Razieh Kamali-Jamil, Michèle G DuVal, Qing Bai, Holger Wille, Edward A Burton, W Ted Allison   +8 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Tryptophan-Tryptophan energy migration as a tool to follow apoflavodoxin folding

, 2008
Submolecular details of Azotobacter vinelandii apoflavodoxin (apoFD) (un)folding are revealed by time-resolved fluorescence anisotropy using wild-type protein and variants lacking one or two of apoFD's three tryptophans.
Mierlo, C.P.M., van, Westphal, Adrie H., van Amerongen, H., Visser, N.V., Amerongen, H., van, van Hoek, Arie, Hoek, A., van, Visser, Antonie J.W.G., van Amerongen, Herbert, van Hoek, A., Visser, Nina V., Westphal, A.H., van Mierlo, Carlo P.M., Visser, A.J.W.G., van Mierlo, C.P.M.   +14 more
core   +1 more source

Relative domain folding and stability of a membrane transport protein [PDF]

, 2014
There is a limited understanding of the folding of multidomain membrane proteins. Lactose permease (LacY) of Escherichia coli is an archetypal member of the major facilitator superfamily of membrane transport proteins, which contain two domains of six ...
Findlay, Heather E., Findlay, Heather E, Harris, Nicola J., Booth, Paula J., Harris, Nicola J, Booth, Paula J, Simms, John, Liu, Xia, Harris, Nicola J; id_orcid   +8 more
core   +1 more source

Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease

Journal of Nanobiotechnology, 2023
Evidence suggests that increased level/aggregation of β-amyloid (Aβ) peptide, together with enhanced phosphorylation/aggregation of tau protein, play a critical role in the development of Alzheimer’s disease (AD), the leading cause of dementia in the ...
Karthivashan Govindarajan, Satyabrata Kar   +1 more
doaj   +1 more source

Tectonic structure of Kerch-Taman fold zone of Azov-Kuban trough

Вестник Камчатской региональной ассоциации "Учебно-научный центр". Серия: Науки о Земле, 2021
The nrotectonic structure of the Kerch-Taman folded zone, the southern deformed part of the Azov-Kuban piedmont trough, has a number of structural features and a history of deformation development.
Гайдаленок О.В., Соколов С.А., Гордеев Н.А.   +2 more
doaj   +1 more source

A galaxy of folds [PDF]

Protein Science, 2009
Abstract Many protein classification systems capture homologous relationships by grouping domains into families and superfamilies on the basis of sequence similarity. Superfamilies with similar 3D structures are further grouped into folds.
Alva, V., Remmert, M., Biegert, A., Lupas, A., Söding, J.   +4 more
openaire   +5 more sources