NiH-Catalyzed Enantio- and Regioselective Hydroselenylation of Unactivated Alkenes. [PDF]
Adv Sci (Weinh)Nickel‐hydride‐catalyzed enantio‐ and regioselective hydroselenylation of unactivated alkenes provides access to chiral organoselenium compounds. Enantiodetermining Ni–H insertion followed by single‐electron diselenide activation generates selenyl radical.
Kang HJ, Kim J, Hong S.
europepmc +2 more sources
Electrochemically Driven Regioselective Radical Functionalization of Allenes: Scope and Mechanistic Insights. [PDF]
Adv Sci (Weinh)Allenes emerge as powerful platforms for electrochemical functionalization through radical pathways. Selective radical addition at the central carbon triggers anodic oxidation and intramolecular cyclization, enabling efficient synthesis of oxazolines and oxazolidine‐2‐imines without external oxidants.
Pyne P +5 more
europepmc +2 more sources
Effects of Selenocysteine Substitution on the Cyclotide Kalata B2. [PDF]
ChembiochemSelenocysteine (Sec) substitution of any of the native complementary cysteine (Cys) residues of the cyclotide kalata B2 preserves the structure, cytotoxicity, and membrane‐binding activity while enhancing its folding efficiency. The study shows the conservative nature and folding benefit of selenocysteine replacement in kalata B2.
de Boda RLB +5 more
europepmc +2 more sources
Direct halo-/seleno-sulfonylation and diselenylation of ynamides mediated by visible light [PDF]
RSC AdvancesBlue LED light-induced double functionalization of ynamides in the presence of tosyl iodide, tosyl bromide, tosyl phenyl selenide, tosyl benzyl selenide, and diphenyl diselenide is reported.
Lucie Almeida Do Amaral +6 more
doaj +2 more sources
Interaction Profile of Diphenyl Diselenide with Pharmacologically Significant Thiols
Molecules, 2012 Diphenyl diselenide has shown interesting biological activities in various free-radical-induced damage models and can be considered as a potential candidate drug against oxidative stress.
João Batista Teixeira Rocha
exaly +3 more sources
Diselenide-bridged hybrid mesoporous silica for radiosensitization and radioprotection in the radioimmunotherapy of colorectal cancer [PDF]
Journal of NanobiotechnologyRadioimmunotherapy has been recognized as a promising strategy for the treatment of colorectal cancer; however, it faces several challenges, including limited efficacy, weak immune activation, and severe radiation-induced colitis. To address these issues,
Fan Zhang +12 more
doaj +2 more sources
Precision Oncology via Radiotherapy-Triggered Drug Delivery: Mechanisms, Molecular Engineering, and Clinical Translation. [PDF]
Adv Sci (Weinh)This review redefines radiotherapy‐triggered drug delivery systems through structural disassembly and molecular actuation, proposing a translation‐oriented framework for dose‐correlated activation to advance clinically integrated precision oncology. ABSTRACT Radiotherapy‐triggered drug delivery systems (RDDS) promise to integrate the spatial precision ...
Jiang J, Zhang T, Dong J, Sun W.
europepmc +2 more sources
Synthesis and Application Dichalcogenides as Radical Reagents with Photochemical Technology
Molecules, 2023 Dichalcogenides (disulfides and diselenides), as reactants for organic transformations, are important and widely used because of their potential to react with nucleophiles, electrophilic reagents, and radical precursors.
Cairong Wang +5 more
doaj +1 more source
Pharmaceutics, 2023 In this study, diselenide (Se–Se) and disulfide (S–S) redox-responsive core-cross-linked (CCL) micelles were synthesized using poly(ethylene oxide)2k-b-poly(furfuryl methacrylate)1.5k (PEO2k-b-PFMA1.5k), and their redox sensitivity was compared. A single
Sonyabapu Yadav +8 more
doaj +1 more source
Molecules, 2022 In the past decade, selenocyclization has been extensively exploited for the preparation of a wide range of selenylated heterocycles with versatile activities.
Hao-Yuan Zhang +6 more
doaj +1 more source