Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies [PDF]
Asian Journal of Pharmaceutical Sciences, 2021 Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more and more attentions. Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage.
Lingxiao Li +9 more
doaj +4 more sources
An On-Demand Dissoluble Chitosan Hydrogel Containing Dynamic Diselenide Bond [PDF]
Gels, 2021 A new kind of on-demand dissolution hydrogel is successfully synthesized by modification of chitosan using γ-selenobutyrolactone. The chitosan hydrogel with different selenium contents is formed by ring opening of γ-selenobutyrolactone with the amines of
Xingxia Xu +4 more
doaj +4 more sources
Reactive Human Plasma Glutathione Peroxidase Mutant with Diselenide Bond Succeeds in Tetramer Formation [PDF]
Antioxidants, 2022 Plasma glutathione peroxidase (GPx3) belongs to the GPx superfamily, and it is the only known secreted selenocysteine (Sec)−containing GPx in humans.
Zhenlin Fan +3 more
doaj +4 more sources
Dynamic diselenide bond‐enabled liquid crystal elastomer‐based two‐way shape memory aerogels with weldability and closed‐loop recyclability [PDF]
Smart Molecules, 2023 Two‐way shape memory polymeric aerogels (2W‐SMPAs), with the ability to undergo reversible shape deformation in response to external stimuli, have extensive application in diverse fields such as actuators, sensors, robotics, and other relevant domains ...
Meng Wang, Jingshu Li, Hong Yang
doaj +3 more sources
Photothermal self-healing polyurethane/graphene oxide composites based on diselenide bond
Polymer Testing, 2023 The polymer PCL-MDI-SeSe-PU polyurethane was synthesized by the reaction of PCL, diisocyanate and a diselenide bond-containing chain extender, and a certain amount of diisocyanate-modified graphene oxide NCO-GO was doped into polyurethane to obtain the ...
Hang Yuan, Chenming Ji, Hua Yuan
doaj +4 more sources
Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity [PDF]
Communications Chemistry, 2023 Seleno-insulin, a class of artificial insulin analogs, in which one of the three disulfide-bonds (S-S’s) of wild-type insulin (Ins) is replaced by a diselenide-bond (Se-Se), is attracting attention for its unique chemical and physiological properties ...
Kenta Arai +11 more
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NiH-Catalyzed Enantio- and Regioselective Hydroselenylation of Unactivated Alkenes. [PDF]
Adv Sci (Weinh)Nickel‐hydride‐catalyzed enantio‐ and regioselective hydroselenylation of unactivated alkenes provides access to chiral organoselenium compounds. Enantiodetermining Ni–H insertion followed by single‐electron diselenide activation generates selenyl radical.
Kang HJ, Kim J, Hong S.
europepmc +2 more sources
Direct halo-/seleno-sulfonylation and diselenylation of ynamides mediated by visible light [PDF]
RSC AdvancesBlue LED light-induced double functionalization of ynamides in the presence of tosyl iodide, tosyl bromide, tosyl phenyl selenide, tosyl benzyl selenide, and diphenyl diselenide is reported.
Lucie Almeida Do Amaral +6 more
doaj +2 more sources
Electrochemically Driven Regioselective Radical Functionalization of Allenes: Scope and Mechanistic Insights. [PDF]
Adv Sci (Weinh)Allenes emerge as powerful platforms for electrochemical functionalization through radical pathways. Selective radical addition at the central carbon triggers anodic oxidation and intramolecular cyclization, enabling efficient synthesis of oxazolines and oxazolidine‐2‐imines without external oxidants.
Pyne P +5 more
europepmc +2 more sources
Effects of Selenocysteine Substitution on the Cyclotide Kalata B2. [PDF]
ChembiochemSelenocysteine (Sec) substitution of any of the native complementary cysteine (Cys) residues of the cyclotide kalata B2 preserves the structure, cytotoxicity, and membrane‐binding activity while enhancing its folding efficiency. The study shows the conservative nature and folding benefit of selenocysteine replacement in kalata B2.
de Boda RLB +5 more
europepmc +2 more sources