An On-Demand Dissoluble Chitosan Hydrogel Containing Dynamic Diselenide Bond [PDF]
Gels, 2021 A new kind of on-demand dissolution hydrogel is successfully synthesized by modification of chitosan using γ-selenobutyrolactone. The chitosan hydrogel with different selenium contents is formed by ring opening of γ-selenobutyrolactone with the amines of
Weihong Lu, Jian Zhu, Xiangqiang Pan
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Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies [PDF]
Asian Journal of Pharmaceutical Sciences, 2021 Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more and more attentions. Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage.
Fudan Dong, Yinxian Yang, Jin Sun
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Diselenide-bond replacement of the external disulfide bond of insulin increases its oligomerization leading to sustained activity [PDF]
Communications Chemistry, 2023 Seleno-insulin, a class of artificial insulin analogs, in which one of the three disulfide-bonds (S-S’s) of wild-type insulin (Ins) is replaced by a diselenide-bond (Se-Se), is attracting attention for its unique chemical and physiological properties ...
Kenta Arai +11 more
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Reactive Human Plasma Glutathione Peroxidase Mutant with Diselenide Bond Succeeds in Tetramer Formation [PDF]
Antioxidants, 2022 Plasma glutathione peroxidase (GPx3) belongs to the GPx superfamily, and it is the only known secreted selenocysteine (Sec)−containing GPx in humans.
Zhenlin Fan +3 more
doaj +4 more sources
Dynamic diselenide bond‐enabled liquid crystal elastomer‐based two‐way shape memory aerogels with weldability and closed‐loop recyclability [PDF]
Smart molecules, 2023 Two‐way shape memory polymeric aerogels (2W‐SMPAs), with the ability to undergo reversible shape deformation in response to external stimuli, have extensive application in diverse fields such as actuators, sensors, robotics, and other relevant domains ...
Meng Wang, Jingshu Li
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Photothermal self-healing polyurethane/graphene oxide composites based on diselenide bond
Polymer Testing, 2023 The polymer PCL-MDI-SeSe-PU polyurethane was synthesized by the reaction of PCL, diisocyanate and a diselenide bond-containing chain extender, and a certain amount of diisocyanate-modified graphene oxide NCO-GO was doped into polyurethane to obtain the ...
Hua Yuan
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Selenoprotein K form an intermolecular diselenide bond with unusually high redox potential [PDF]
FEBS Letters, 2014 Selenoprotein K (SelK) is a membrane protein involved in antioxidant defense, calcium regulation and the ER‐associated protein degradation pathway. We found that SelK exhibits a peroxidase activity with a rate that is low but within the range of other peroxidases.
Sharon Rozovsky
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Synthesis and activity of a diselenide bond mimetic of the antimicrobial protein caenopore-5. [PDF]
Chem Sci, 2016 Antimicrobial proteins are a rich source of new lead compounds for the development of new drugs that will tackle global resistance towards existing antibiotics.
Medini K +5 more
europepmc +5 more sources
Science and Technology of Advanced Materials, 2020 We report the dynamic behavior of diselenide-containing hydrophilic polyurethanes and hydrogels based on diselenide exchange reactions in an aqueous media.
Akira Takahashi +2 more
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Selenium nanoparticles with bioorthogonal targeting to boost CAR-cell therapy for colorectal cancer [PDF]
Journal of NanobiotechnologyThe treatment of solid tumors with chimeric antigen receptor natural killer (CAR-NK) cell therapy confronts significant barriers, notably poor cellular infiltration and a highly immunosuppressive tumor microenvironment (TME). To overcome these challenges,
Jinfan Zhou +13 more
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