Results 11 to 20 of about 2,674 (194)

Diselenide-Bridged Doxorubicin Dimeric Prodrug: Synthesis and Redox-Triggered Drug Release

Molecules
The diselenide bond has attracted intense interest in redox-responsive drug delivery systems (DDSs) in tumor chemotherapy, due to its higher sensitivity than the most investigated bond, namely the disulfide bond.
Peng Liu
exaly   +4 more sources

Visible Light-Induced Templated Metathesis of Peptide–Nucleic Acid Conjugates with a Diselenide Bridge

Biomolecules, 2023
The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids.
Mateusz Waliczek, Wiktoria Gancarz, Paulina Pochwała, Özge Pehlivan, Piotr Stefanowicz   +4 more
doaj   +2 more sources

Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif [PDF]

Proceedings of the National Academy of Sciences, 2007
Selenocysteine (Sec, U) insertion into proteins is directed by translational recoding of specific UGA codons located upstream of a stem-loop structure known as Sec insertion sequence (SECIS) element. Selenoproteins with known functions are oxidoreductases containing a single redox-active Sec in their active sites.
Shchedrina, Valentina A., Novoselov, Sergey V., Malinouski, Mikalai I., Gladyshev, Vadim N.   +3 more
openaire   +4 more sources

Synthesis of 3,4-Bis(Butylselanyl)Selenophenes and 4-Alkoxyselenophenes Promoted by Oxone^®

Molecules, 2021
We describe herein an alternative transition-metal-free procedure to access 3,4-bis(butylselanyl)selenophenes and the so far unprecedented 3-(butylselanyl)-4-alkoxyselenophenes. The protocol involves the 5-endo-dig electrophilic cyclization of 1,3-diynes
Paola S. Hellwig, Jonatan S. Guedes, Angelita M. Barcellos, Gelson Perin, Eder J. Lenardão   +4 more
doaj   +2 more sources

Diselenide Bonds as an Alternative to Outperform the Efficiency of Disulfides in Self-Healing Materials

The Journal of Organic Chemistry, 2019
Self-healing materials are a very promising kind of materials due to their capacity to repair themselves. Among others, dichalcogenide-based materials are widely studied due to their dynamic covalent bond nature. Recently, the reaction mechanism occurring in these materials was characterized both theoretically and experimentally.
Mikel Irigoyen, Andrea Fernández, Amaia Ruiz, Fernando Ruipérez, Jon M. Matxain   +4 more
openaire   +3 more sources

Bis(furan-2-ylcarbonyl) diselenide

Acta Crystallographica Section E, 2011
The title molecule, C10H6O4Se2, lies on a twofold rotation axis. The Se—Se bond length of 2.305 (3) Å is similar to that in diphenyl diselenide [2.3066 (7) and 2.3073 (10) &#197 ...
David B. Cordes, Guoxiong Hua, Alexandra M. Z. Slawin, J. Derek Woollins   +3 more
doaj   +2 more sources

Abnormal Enhancement of Protein Disulfide Isomerase-like Activity of a Cyclic Diselenide Conjugated with a Basic Amino Acid by Inserting a Glycine Spacer

Biology, 2021
In a previous study, we reported that (S)-1,2-diselenane-4-amine (1) catalyzes oxidative protein folding through protein disulfide isomerase (PDI)-like catalytic mechanisms and that the direct conjugation of a basic amino acid (Xaa: His, Lys, or Arg) via
Rumi Mikami, Shunsuke Tsukagoshi, Kenta Arai   +2 more
doaj   +2 more sources

Design of pH/Redox Co-Triggered Degradable Diselenide-Containing Polyprodrug via a Facile One-Pot Two-Step Approach for Tumor-Specific Chemotherapy

Molecules
The diselenide bond has attracted intense interest for drug delivery systems (DDSs) for tumor chemotherapy, owing to it possessing higher redox sensitivity than the disulfide one.
Yanru Hu, Peng Liu
doaj   +2 more sources

A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway [PDF]

Bioactive Materials
Prolonged periodontal inflammation and progressive alveolar bone loss are typical manifestations of periodontitis. Antioxidative therapies targeting the central role of reactive oxygen species (ROS) have been explored, but lack of subcellular specificity
Ning Huang, Lingyan Cao, Yue Xu, Lisha Pan, Ao Zheng, Xiao Wang, Xinquan Jiang   +6 more
doaj   +2 more sources

Thermally Driven Diselenide Metathesis: Polarization Process vs Radical Process

, 2022
Diselenide, as a dynamic covalent bond, has been widely applied in functional materials due to its response to light, heat, sonication, pH, and other stimuli. Herein, a polarization-induced metathesis mechanism for diselenides under heating conditions in
Jiandong Zhang (818773), Sisi Chen, Hanliang He, Hanliang He (12007712), Jian Zhu (126278), Weihong Lu, Xiangqiang Pan, Jiandong Zhang, Xiangqiang Pan (1626793), Yujie Cang (12007715), Jian Zhu, Yujie Cang, Sisi Chen (166395), Weihong Lu (555228)   +13 more
core   +3 more sources