Results 21 to 30 of about 2,674 (194)

Selenium-functionalized polycarbonate-polyurethane for sustained in situ generation of therapeutic gas for blood-contacting materials

Smart Materials in Medicine, 2022
Polyurethanes (PU) have been widely used in blood-contacting devices including indwelling implants and extracorporeal devices due to its good biocompatibility.
Peichuang Li, Wanhao Cai, Kebing Wang, Lei Zhou, Shusheng Tang, Yuancong Zhao, Xin Li, Jin Wang   +7 more
doaj   +1 more source

Clarification on the Reactivity of Diaryl Diselenides toward Hexacyclohexyldilead under Light

Molecules, 2021
In this study, the reactivity of organochalcogen compounds toward a representative alkyl-lead bond compound under light was investigated in detail.
Vu Thai Hung, Cong Chi Tran, Yuki Yamamoto, Shintaro Kodama, Akihiro Nomoto, Akiya Ogawa   +5 more
doaj   +1 more source

Integration of a Diselenide Unit Generates Fluorogenic Camptothecin Prodrugs with Improved Cytotoxicity to Cancer Cells

, 2021
A diselenide/disulfide unit was introduced into camptothecin (CPT), and two selenoprodrugs (e.g., CPT–Se3 and CPT–Se4) were identified to show improved potency in killing cancer cells and inhibiting tumor growth in vivo.
Jintao Zhao (10309677), Jianguo Fang (1375440), Qianhe Xu, Bingbing Chang, Xinming Li, Bingbing Chang (3624476), Miao Zhong, Xinming Li (143063), Zihua Wang, Jintao Zhao, Miao Zhong (313963), Qianhe Xu (6387377), Jianguo Fang, Zihua Wang (290751)   +13 more
core   +2 more sources

Regio- and Stereoselective Synthesis of (Z,Z)-Bis(3-amino-3-oxo-1-propenyl) Selenides and Diselenides Based on 2-propynamides: A Novel Family of Diselenides with High Glutathione Peroxidase-like Activity

Inorganics, 2022
The efficient regio- and stereoselective syntheses of (Z,Z)-bis(3-amino-3-oxo-1-propenyl) selenides and diselenides in high yields based on the nucleophilic addition of sodium selenide to 2-propynamides and sodium diselenide to 3-(trimethylsilyl)-2 ...
Vladimir A. Potapov, Mikhail V. Andreev, Maxim V. Musalov, Irina V. Sterkhova, Svetlana V. Amosova, Lyudmila I. Larina   +5 more
doaj   +1 more source

Synthesis and Biological Evaluation of 2-Picolylamide-Based Diselenides with Non-Bonded Interactions [PDF]

Molecules, 2015
In this paper, we report the synthesis and biological evaluation of picolylamide-based diselenides with the aim of developing a new series of diselenides with O···Se non-bonded interactions. The synthesis of diselenides was performed by a simple and efficient synthetic route.
Jamal Rafique, Sumbal Saba, Rômulo Canto, Tiago Frizon, Waseem Hassan, Emily Waczuk, Maryam Jan, Davi Back, João Da Rocha, Antonio Braga   +9 more
openaire   +4 more sources

1,1′-(Diselanediylbis{[P,P-diphenyl-N-(trimethylsilyl)phosphorimidoyl]methanylylidene})bis[1,1-diphenyl-N-(trimethylsilyl)-λ5-phosphanamine] pentane disolvate

Acta Crystallographica Section E, 2014
The title compound, C62H78N4P4Se2Si4·2C5H12, is made up of two [SeC(PPh2NSiMe3)(PPh2NHSiMe3)] units related by an inversion center situated at the mid-point of the diselenide bond.
Ramalingam Thirumoorthi, Tristram Chivers, Risto S. Laitinen   +2 more
doaj   +1 more source

Crystal structure, Hirshfeld surface analysis and DFT study of 2,2′′-({[(1E,1′E)-(diselanediyl)bis(2,1-phenylene)]bis(methaneylylidene)}bis(azaneylylidene))bis[3′,6′-bis(diethylamino)-4a',9a'-dihydrospiro[isoindoline-1,9′-xanthen]-3-one]

Acta Crystallographica Section E: Crystallographic Communications, 2022
The title compound, C70H70N8O4Se2, is a spiro bicyclic diselenide, made up of two [SeC6H4CH=N—N(CO)C6H4(C)C6H3NEt2(O)C6H3NEt2] units related by a twofold crystallographic symmetry element bisecting the diselenide bond.
Manzoor Ahmad Malla, Ravi Bansal, Ray J. Butcher, Sushil K. Gupta   +3 more
doaj   +1 more source

Insights into stimuli-responsive diselenide bonds utilized in drug delivery systems for cancer therapy

Biomedicine & Pharmacotherapy, 2022
Due to the complexity and particularity of cancer cell microenvironments, redox responsive drug delivery systems (DDSs) for cancer therapy have been extensively explored. Compared with widely reported cancer treatment systems based on disulfide bonds, diselenide bonds have better redox properties and greater anticancer efficiency.
Zhenfeng, Shi, Jifang, Liu, Lei, Tian, Jingyi, Li, Yue, Gao, Yue, Xing, Wenjing, Yan, Chenyu, Hua, Xiaolin, Xie, Chang, Liu, Chengyuan, Liang   +10 more
openaire   +2 more sources

Catalytic Antioxidant Activity of Bis-Aniline-Derived Diselenides as GPx Mimics

Molecules, 2021
Herein, we describe a simple and efficient route to access aniline-derived diselenides and evaluate their antioxidant/GPx-mimetic properties. The diselenides were obtained in good yields via ipso-substitution/reduction from the readily available 2 ...
Giancarlo V. Botteselle, Welman C. Elias, Luana Bettanin, Rômulo F. S. Canto, Drielly N. O. Salin, Flavio A. R. Barbosa, Sumbal Saba, Hugo Gallardo, Gianluca Ciancaleoni, Josiel B. Domingos, Jamal Rafique, Antonio L. Braga   +11 more
doaj   +1 more source

Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy

Nature Communications, 2019
Tumor cells are characterized as redox-heterogeneous intracellular microenvironment due to the simultaneous overproduction of reactive oxygen species and glutathione.
Bingjun Sun, Cong Luo, Xuanbo Zhang, Mengran Guo, Mengchi Sun, Han Yu, Qin Chen, Wenqian Yang, Menglin Wang, Shiyi Zuo, Pengyu Chen, Qiming Kan, Haotian Zhang, Yongjun Wang, Zhonggui He, Jin Sun   +15 more
doaj   +1 more source