Results 1 to 10 of about 1,340 (95)

Sulfur incorporation into biomolecules: recent advances. [PDF]

open access: yesCrit Rev Biochem Mol Biol, 2022
Sulfur is an essential element for a variety of cellular constituents in all living organisms and adds considerable functionality to a wide range of biomolecules. The pathways for incorporating sulfur into central metabolites of the cell such as cysteine,
Chatterjee S, Hausinger RP.
europepmc   +2 more sources

Thermodynamic and structural contributions of the 6-thioguanosine residue to helical properties of RNA. [PDF]

open access: yesSci Rep, 2019
Thionucleotides, especially 4-thiouridine and 6-thioguanosine, are photosensitive molecules that photocrosslink to both proteins and nucleic acids, and this feature is a major reason for their application in various investigations.
Gładysz M   +4 more
europepmc   +2 more sources

Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA. [PDF]

open access: yesFree Radic Biol Med, 2017
UVA accounts for about 95% of the solar ultraviolet (UV) radiation that reaches Earth and most likely contributes to human skin cancer risk. In contrast to UVB, which comprises the remaining 5% and is absorbed by DNA nucleobases to cause direct ...
Brem R, Guven M, Karran P.
europepmc   +2 more sources

Nucleoside cyclic 3′,5′-phosphorothioates with purine and pyrimidine scaffolds. A chemical minireview

open access: yesEuropean Journal of Medicinal Chemistry Reports, 2022
The common nucleobases purine (adenine and guanine) and pyrimidine (cytosine, uracil and thymine) in naturally occurring nucleosides and their 3′,5′-cyclic phosphates are β-bonded to the anomeric carbon (C1′) of d-ribose or its 2′-deoxy congener.
Kjell Undheim
doaj   +1 more source

Studies on tyrosine transfer ribonucleic acid, a sulfur-rich species from Escherichia coli.

open access: yesJournal of Biological Chemistry, 1967
A purified species of tyrosine transfer RNA has been isolated by countercurrent techniques and shown to contain 2 4-thiouridylate residues per molecule. These thionucleotides may be titrated quantitatively with p-hydroxymercuribenzoate.
M. Lipsett, B. P. Doctor
semanticscholar   +1 more source

The isolation of 4-thiouridylate disulfide from oxidized transfer ribonucleic acid of Escherichia coli.

open access: yesJournal of Biological Chemistry, 1967
The formation of disulfide bonds between thionucleotides of transfer RNA has been postulated to occur during oxidation with iodine. In this paper, the actual isolation of 4-thiouridylate disulfide from oxidized transfer RNA is described.
M. Lipsett
semanticscholar   +1 more source

Calcium transport and ATPase activities of sarcoplasmic reticulum with adenosine 5'-O-(2-thiotriphosphate) diastereomers as substrates.

open access: yesJournal of Biological Chemistry, 1982
The correspondence between the magnitude of the free energy of hydrolysis of ATP and the f ree energy involved in the Ca2+ gradient in sarcoplasmic reticulum (SR) vesicles was tested by substitution of either diastereomers of adenosine 5’-0-(2 ...
E. Pintado, A. Scarpa, M. Cohn
semanticscholar   +1 more source

Template-prime-dependent turnover of (Sp)-dATP alpha S by T4 DNA polymerase. The stereochemistry of the associated 3' goes to 5'-exonuclease.

open access: yesJournal of Biological Chemistry, 1982
T4 DNA polymerase converts (Sp)-2'-deoxyadenosine 5'-O-(1-thio[1-18O2]triphosphate) to 2'-deoxyadenosine 5'-O-[18O]-phosphorothioate in the presence of poly(d(A-T).poly(d(A-T)) template-primer. Control experiments involving either omitting the poly(d(A-T)
A. Gupta, C. Debrosse, S. Benkovic
semanticscholar   +1 more source

31P NMR quantitation of the displacement of equilibria of arginine, creatine, pyruvate, and 3-P-glycerate kinase reactions by substitution of sulfur for oxygen in the beta phosphate of ATP.

open access: yesJournal of Biological Chemistry, 1980
31P NMR measurements have been found to be a convenient means for simultaneously measuring the concentrations of several species in the equilibrium mixtures of the reactions catalyzed by arginine kinase and creatine kinase. MgATP + X in equilibrium MgADP
C. L. Lerman, M. Cohn
semanticscholar   +1 more source

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