The Enzymes of Biotin Dependent CO(2) Metabolism: What Structures Reveal about Their Reaction Mechanisms [PDF]
, 2012 Biotin is the major cofactor involved in carbon dioxide metabolism. Indeed, biotin-dependent enzymes are ubiquitous in nature and are involved in a myriad of metabolic processes including fatty acid synthesis and gluconeogenesis. The cofactor, itself, is
Holden, Hazel M +2 more
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Identification of the Xenopus DNA2 protein as a major nuclease for the 5′→3′ strand-specific processing of DNA ends [PDF]
The first step of homology-dependent DNA double-strand break (DSB) repair is the 5′ strand-specific processing of DNA ends to generate 3′ single-strand tails.
Baumann +26 more
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Inhibition of Yeast Hexokinase by the Antimalarial Drug Artemisinin: Probing Mechanism of Action with a Model Enzyme [PDF]
, 2009 A leading infectious cause of death, malaria threatens approximately half of the world\u27s population, and drug-resistant strains of Plasmodium falciparum have created immense difficulty in chemotherapy of the disease.
Spence, Jennifer S.
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Metal Ion Complexes of Nuceloside Phosphorothioates Reflecting the Ambivalent Properties of Lead (II) [PDF]
, 2018 This Perspective outlines the coordinating properties of lead( II ), to some extent in comparison with related metal ions like Ca 2+ , Zn 2+ or Cd 2+ . It is worth noting that the affinity of Pb 2+ towards phosphate residues corresponds to that of Cu 2+ .
Operschall, Bert P. +3 more
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Studies Towards Nucleic Acids at the Origins of Life [PDF]
, 2021 Nucleic acids are at the heart of extant biology and the structure of life’s original genetic polymer is still a question of debate. The RNA world theory proposes that RNA was the first nucleic acid employed as life’s genetic polymer due to its dual ...
Colville, Ben W.F.
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Genetic analysis of the human tumor necrosis factor alpha/cachectin promoter region in a macrophage cell line. [PDF]
, 1989 The 615-bp 5' flanking region of the human TNF-alpha/cachectin gene was isolated and ligated to the luciferase reporter gene. In addition, a series of truncated promoter constructs was generated by exonuclease III digestion.
Economou, JS +5 more
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Hybrid modelling of biological systems using fuzzy continuous Petri nets [PDF]
, 2019 Copyright © The Author(s) 2019. Integrated modelling of biological systems is challenged by composing components with sufficient kinetic data and components with insufficient kinetic data or components built only using experts’ experience and knowledge ...
Gilbert, D, Heiner, M, Liu, F, Sun, W
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Structure−Activity Relationships of Uridine 5‘-Diphosphate Analogues at the Human P2Y 6 Receptor [PDF]
, 2006 The structure activity relationships and molecular modeling of the uracil nucleotide-activated P2Y6 receptor have been studied. A series of UDP analogues bearing substitutions of the ribose moiety, the uracil ring, and the diphosphate group was ...
Besada, Pedro +9 more
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Determining the Function and ATPase/RNA Remodeling Cycle of Dbp5 [PDF]
, 2022 Dbp5 from Saccharomyces cerevisiae is an essential DEAD-box protein required for many aspects of mRNA metabolism including nuclear mRNA export. The ATPase cycle of Dbp5 is required for its in vivo function in mRNA export. The Dbp5 ATPase cycling kinetics
Gray, Shawn Dean
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Structural Requirements for Protein Function Studied by in Vitro Mutagenesis on Beta-Lactamase [PDF]
, 1985 The study of naturally occurring variants of proteins has been successfully used for a long time to assign roles to structural elements in a protein and to correlate functional requirements with the nature of these structural elements.
Dalbadie-McFarland, Gloria
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