Metal Ion Complexes of Nuceloside Phosphorothioates Reflecting the Ambivalent Properties of Lead (II) [PDF]
, 2018 This Perspective outlines the coordinating properties of lead( II ), to some extent in comparison with related metal ions like Ca 2+ , Zn 2+ or Cd 2+ . It is worth noting that the affinity of Pb 2+ towards phosphate residues corresponds to that of Cu 2+ .
Operschall, Bert P. +3 more
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Genetic analysis of the human tumor necrosis factor alpha/cachectin promoter region in a macrophage cell line. [PDF]
, 1989 The 615-bp 5' flanking region of the human TNF-alpha/cachectin gene was isolated and ligated to the luciferase reporter gene. In addition, a series of truncated promoter constructs was generated by exonuclease III digestion.
Economou, JS +5 more
core
Structure−Activity Relationships of Uridine 5‘-Diphosphate Analogues at the Human P2Y 6 Receptor [PDF]
, 2006 The structure activity relationships and molecular modeling of the uracil nucleotide-activated P2Y6 receptor have been studied. A series of UDP analogues bearing substitutions of the ribose moiety, the uracil ring, and the diphosphate group was ...
Besada, Pedro +9 more
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Chemical Synthesis of Modified RNA
Angewandte Chemie International Edition, Volume 63, Issue 22, May 27, 2024.Recent developments in the field of chemical RNA synthesis are discussed, starting with protection concepts, followed by selected nucleoside modifications that are challenging to incorporate into RNA. Comments on the chemical synthesis of 5′‐capped mRNAs, the enzymatic ligation of synthetic RNA, and RNA‐catalyzed RNA modifications using cofactors that ...
Laurin Flemmich +2 more
wiley +1 more source
ChemElectroChem, Volume 11, Issue 1, January 2, 2024.Electrosynthesis of artificial peptides and nucleosides: Electrosynthetic methodologies have frequently found application in chemical production processes. In the past few decades, the MeNO2‐LiClO4 electrolyte system has significantly enhanced the reactivity of cationic species in oxidative electrochemical reactions.
Kazuhiro Okamoto, Kazuhiro Chiba
wiley +1 more source
Thioesters Support Efficient Protein Biosynthesis by the Ribosome [PDF]
Thioesters are critical chemical intermediates in numerous extant biochemical reactions and are invoked as key reagents during prebiotic peptide synthesis on an evolving Earth.
Cate, Jamie HD +9 more
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Determining the Function and ATPase/RNA Remodeling Cycle of Dbp5 [PDF]
, 2022 Dbp5 from Saccharomyces cerevisiae is an essential DEAD-box protein required for many aspects of mRNA metabolism including nuclear mRNA export. The ATPase cycle of Dbp5 is required for its in vivo function in mRNA export. The Dbp5 ATPase cycling kinetics
Gray, Shawn Dean
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Bootstrapping Erklärbarer Text-Kategorisierung in Emergenten Wissensdomänen [PDF]
, 2021 Text Categorization (TC) is the act of assigning text documents to predefined categories. For instance, to distinguish between pro- and contra arguments for a specific topic.
Eljasik-Swoboda, Tobias
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Structural Requirements for Protein Function Studied by in Vitro Mutagenesis on Beta-Lactamase [PDF]
, 1985 The study of naturally occurring variants of proteins has been successfully used for a long time to assign roles to structural elements in a protein and to correlate functional requirements with the nature of these structural elements.
Dalbadie-McFarland, Gloria
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Computing Network of Diseases and Pharmacological Entities through the Integration of Distributed Literature Mining and Ontology Mapping [PDF]
, 2011 The proliferation of -omics (such as, Genomics, Proteomics) and -ology (such as, System Biology, Cell Biology, Pharmacology) have spawned new frontiers of research in drug discovery and personalized medicine.
Faisal, Fazle Elahi
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