Computing Network of Diseases and Pharmacological Entities through the Integration of Distributed Literature Mining and Ontology Mapping [PDF]
, 2011 The proliferation of -omics (such as, Genomics, Proteomics) and -ology (such as, System Biology, Cell Biology, Pharmacology) have spawned new frontiers of research in drug discovery and personalized medicine.
Faisal, Fazle Elahi
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Characterization of SufS and SufE of Suf Pathway for FE-S Cluster Assembly in Escherichia Coli [PDF]
, 2017 Fe-S clusters are one major type of the sulfur-containing cofactors, which conduct essential functions in organisms. The Suf pathway is one of the three main pathways for the biosynthesis of Fe-S clusters. In E.
Dong, Guangchao
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Cyclic di-AMP in bacterial homeostasis: from membrane-bound synthesis and stress sensing to transport [PDF]
The thesis investigates the synthesis and transport of cyclic di-AMP in Lactococcus lactis.Chapter1 introduces cyclic di-AMP's role in bacterial osmotic homeostasis. Chapter2 focuses on the function and structure of the synthetase for cyclic di-AMP, CdaA,
Li, Haoyang
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"2'-deoxy-6-thioguanosine :synthesis of monomer, oligomers and long DNA, and their binding with metal ions [PDF]
, 2013 PhD ThesisThe formation of one-dimensional (1D) coordination polymers using thiolated DNA nucleosides and nucleotides with transition metals was investigated. 2’-Deoxy-6- 1 13 thioguanosine was successfully synthesised and characterized by H-NMR,
Hribesh, Samira
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Functional and structural characterization of the mevalonate diphosphate decarboxylase and the isopentenyl diphosphate isomerase from Enterococcus faecalis [PDF]
, 2016 Enterococcus faecalis causes a diverse range of nosocomial infections (in wounds, the gastrointestinal tract, the blood stream and the endocardium), and multidrug-resistant strains have become a serious issue across countries.
Chen, Chun-Liang
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Functional and structural characterization of Aquifex aeolicus sulfide:quinone oxidoreductase [PDF]
, 2010 This work presents the first complete structure of the membrane protein sulfide:quinone oxidoreductase (SQR), obtained by X-ray crystallography. Its description is complemented by the results of biochemical and functional experiments. SQRs are ubiquitous
Marcia, Marco
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Aptamer Sensors for Drugs of Abuse and Medical Biomarkers: Design, Engineering and Application in Complex Samples [PDF]
, 2018 Aptamers are short oligonucleotide sequences (DNA or RNA) capable of high affinity and specific binding to a molecule or a family of molecules. Aptamers are lower in cost and exhibit higher reproducibility when compared to antibodies and thus are well ...
Roncancio, Daniel
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The nucleotide binding domains of multidrug resistance-p-glycoproteins [PDF]
, 2001 Bibliography: leaves 116 ...
De Wet, Heidi
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Satisfaction of Clinical Teachers on Standardized Residency Training Program (SRTP) in China: A Cross-Sectional Survey. [PDF]
Int J Environ Res Public Health, 2022 Chen B, Jin X, Zhou J, Chen Y, Wang H.
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LACTONE-CARBOXYLATE INTERCONVERSION AS A DETERMINANT OF THE CLEARANCE AND ORAL BIOAVAILABILTY OF THE LIPOPHILIC CAMPTOTHECIN ANALOG AR-67 [PDF]
, 2010 The third generation camptothecin analog, AR-67, is undergoing early phase clinical trials as a chemotherapeutic agent. Like all camptothecins it undergoes pH dependent reversible hydrolysis between the lipophilic lactone and the hydrophilic carboxylate.
Adane, Eyob Debebe
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