LACTONE-CARBOXYLATE INTERCONVERSION AS A DETERMINANT OF THE CLEARANCE AND ORAL BIOAVAILABILTY OF THE LIPOPHILIC CAMPTOTHECIN ANALOG AR-67 [PDF]
, 2010 The third generation camptothecin analog, AR-67, is undergoing early phase clinical trials as a chemotherapeutic agent. Like all camptothecins it undergoes pH dependent reversible hydrolysis between the lipophilic lactone and the hydrophilic carboxylate.
Adane, Eyob Debebe
core +1 more source
Satisfaction of Clinical Teachers on Standardized Residency Training Program (SRTP) in China: A Cross-Sectional Survey. [PDF]
Int J Environ Res Public Health, 2022 Chen B, Jin X, Zhou J, Chen Y, Wang H.
europepmc +1 more source
The nucleotide binding domains of multidrug resistance-p-glycoproteins [PDF]
, 2001 Bibliography: leaves 116 ...
De Wet, Heidi
core
Clinical impacts of scar reduction on gated myocardial perfusion SPECT after cardiac resynchronization therapy. [PDF]
J Nucl Cardiol, 2022 Wang CY +10 more
europepmc +1 more source
Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine. [PDF]
Ther Drug Monit, 2021 Bayoumy AB +7 more
europepmc +1 more source
Studies of the recombinant plasmids carrying the adh mutation of escherichia coli. [PDF]
, 1994 Geok-yen Yeo.Thesis (M.Phil.)--Chinese University of Hong Kong, 1994.Includes bibliographical references (leaves 225-233).Title page --- p.iMembers of Thesis Advisory Committee --- p.iiAbstract --- p.iii -ivAcknowledgments --- p.vDedication --- p ...
core
Biomarkers for gastrointestinal adverse events related to thiopurine therapy. [PDF]
World J Gastroenterol, 2021 Zudeh G, Franca R, Stocco G, Decorti G.
europepmc +1 more source
The role of Di-iron proteins in pathogen resistance [PDF]
, 2012 Dissertation presented to obtain the Ph.D. degree in BiochemistryReactive oxygen and nitrogen species (ROS and RNS) are produced by phagocytic cells of the human immune system to attack invading pathogens due to their ability to damage DNA and the ...
Baptista, Joana Morais
core
"Pharmacogenetics of Cancer" - Cancer Drug Resistance special issue. [PDF]
Cancer Drug Resist, 2020 Mini E, Nobili S.
europepmc +1 more source
Ribonuclease P Catalysis: Metal Ion Interaction and Conformational Dynamics [PDF]
, 2015 RNase P is responsible for catalyzing the 5’-end maturation of precursor tRNAs (pre-tRNAs). The catalytic RNA subunit of bacterial RNase P is essential for activity.
Chen, Yu
core