6-Thioguanosine Monophosphate Prodrugs Display Enhanced Performance against Thiopurine-Resistant Leukemia and Breast Cancer Cells. [PDF]
J Med Chem, 2022 Moreno S +8 more
europepmc +1 more source
Ribonuclease P Catalysis: Metal Ion Interaction and Conformational Dynamics [PDF]
, 2015 RNase P is responsible for catalyzing the 5’-end maturation of precursor tRNAs (pre-tRNAs). The catalytic RNA subunit of bacterial RNase P is essential for activity.
Chen, Yu
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The Development and Evaluation of Novel Reagents for Pre-Targeted Radioimmunotherapy [PDF]
, 2004 PhDIn a pretargeting radioimmunotherapy system, monoclonal antibodies (MAbs) derivatised with a high affinity streptavidin receptor are used in a localisation step.
Hainsworth, James Edward Scott
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Green Management and Sustainable Performance of Small- and Medium-Sized Hospitality Businesses: Moderating the Role of an Employee's Pro-Environmental Behaviour. [PDF]
Int J Environ Res Public Health, 2023 Elshaer IA, Azazz AMS, Fayyad S.
europepmc +1 more source
Kinetic studies on the fidelity of DNA replication involving DNA templates containing O6-methylguanine [PDF]
, 1993 Production by N-nitroso compounds of O6-alkylguanine (O6-alkylG) in DNA directs the misincorporation of thymine during DNA replication, leading to G:C to A:T transition mutations, despite the fact that DNA containing O6>alkylG:T base-pairs is less ...
Tan, Hwee Boon
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GSDMD knockdown attenuates phagocytic activity of microglia and exacerbates seizure susceptibility in TLE mice. [PDF]
J Neuroinflammation, 2023 Yang X, Cao Q, Guo Y, He J, Xu D, Lin A.
europepmc +1 more source
Some studies on the low molecular weight RNA components of mammalian cells [PDF]
, 1971 Until recently, RNA was considered to belong to one of three categories; transfer RNA(tRNA), ribosomal RNA or messenger RNA. In addition however, the development of more sophisticated analytical techniques such as polyacrylamide gel electrophoresis ...
Clason, Alexander E
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ATP-binding cassette subfamily C (ABCC) transporter 1 (ABCC1) and 4 (ABCC4) independent of their drug efflux ability affects breast cancer biology [PDF]
Breast cancer treatment has been a challenge to date, due in part to cancer cells acquiring drug resistance. One of the mechanisms by which resistance can occur is the overexpression of drug efflux pumps such as ATP-binding cassette, subfamily C (ABCC ...
Low, Floren
core +1 more source
Études Structurales par Résonance Magnétique Nucléaire (RMN) du Site Actif du Ribozyme VS de Neurospora [PDF]
, 2008 Nous étudions le ribozyme VS de Neurospora, en tant que système modèle, pour augmenter nos connaissances sur la relation entre la structure et la fonction chez les ARNs, ainsi que pour mieux comprendre le mécanisme de clivage de ce ribozyme.
Desjardins-Séguin, Geneviève
core +1 more source
Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction. [PDF]
J Am Chem Soc, 2021 Darrah K +5 more
europepmc +1 more source