Results 71 to 80 of about 7,079 (242)
Arquivos de Gastroenterologia, 2012 CONTEXT: The use of thiopurine drugs such as azathioprine and 6-mercaptopurine has become quite common in the treatment of inflammatory bowel disease, transplantation and acute leukemias.
Gabriela Roncone Gastal +5 more
doaj +1 more source
Phenome-wide association studies on a quantitative trait: application to TPMT enzyme activity and thiopurine therapy in pharmacogenomics. [PDF]
PLoS Computational Biology, 2013 Phenome-Wide Association Studies (PheWAS) investigate whether genetic polymorphisms associated with a phenotype are also associated with other diagnoses.
Antoine Neuraz +9 more
doaj +1 more source
Structural term extraction for expansion of template-based genomic queries [PDF]
, 2005 This paper describes our experiments run to address the ad hoc task of the TREC 2005 Genomics track. The task topics were expressed with 5 different structures called Generic Topic Templates (GTTs). We hypothesized the presence of GTT-specific structural
Blott, Stephen +4 more
core
Economic Evaluation of Pharmacogenetic Tests in Patients Subjected to Renal Transplantation: A Review of Literature [PDF]
, 2016 Renal transplantation is the treatment of choice for the patients with end-stage renal failure. Genetic factors, among others, can influence variability in response to immunosuppressive drugs.
Aleksandra Kovacevic +5 more
core +2 more sources
The first live term birth following uterus transplantation in Australia
Medical Journal of Australia, Volume 223, Issue 8, Page 404-409, October 2025.Abstract Objective To report the first live birth following uterus transplantation in Australia. Study design Case report. Setting, participant The first participant in the uterus transplantation research study program at the Royal Hospital for Women, the Prince of Wales Hospital, and Westmead Hospital in Sydney.
Rebecca Deans +21 more
wiley +1 more source
Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children. [PDF]
, 2016 Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to ...
Dale, Rc, Lim, M., Nosadini, M
core +3 more sources
Dual Malignancies in IgG4‐Related Disease: A Diagnostic and Therapeutic Challenge
ACR Open Rheumatology, Volume 7, Issue 10, October 2025.We report a rare case of IgG4‐related disease (IgG4‐RD) presenting with retroperitoneal fibrosis and autoimmune pancreatitis, followed by sequential development of papillary thyroid carcinoma and diffuse large B cell lymphoma. Histopathologic and positron emission tomography–computed tomography findings were essential for diagnosis and guided timely ...
Ji Li +4 more
wiley +1 more source
Journal of Pediatric Research, 2022 Aim:Thiopurine S-methyltransferase (TPMT) is an essential enzyme in the metabolism of thiopurine drugs, and its activity may change due to different polymorphisms in the TPMT gene.
Eda Ataseven +4 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 3, Page 682-692, September 2025.Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann +6 more
wiley +1 more source
Thiopurine S-Methyltransferase Polymorphism in Iraqi Paediatric Patients with Acute Lymphoblastic Leukaemia [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Acute Lymphoblastic Leukaemia (ALL) treatment protocols widely used thiopurine drugs as an anti-cancer agent, which over the course of time results in drug toxicity.
NAWARS MOHAMMED +2 more
doaj +1 more source