Pharmacogenetics in Type 2 Diabetes: Potential Implications for Clinical Practice [PDF]
, 2013 Pharmacogenetic research aims to study how genetic variation may influence drug efficacy and/or toxicity; pharmacogenomics expands this quest to the entire genome. Pharmacogenetic findings may help to uncover new drug targets, illuminate pathophysiology,
Florez, Jose Carlos, Huang, Chunmei
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Journal of Pediatric Gastroenterology and Nutrition, Volume 81, Issue 3, Page 765-815, September 2025.Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Eytan Wine +24 more
wiley +1 more source
COLLAB: A Global Survey of Clinical and Laboratory Assessment in Alopecia Areata by Hair Specialists
JEADV Clinical Practice, Volume 4, Issue 4, Page 811-820, September 2025.Guidelines for alopecia areata recommend that baseline investigations are unnecessary, but is this standard practice among hair loss experts worldwide? This global study showed high rates of laboratory testing of patients with alopecia areata, particularly related to autoimmune co‐morbidities.
Cathal O'Connor +39 more
wiley +1 more source
Pharmacogenomics in children: advantages and challenges of next generation sequencing applications [PDF]
, 2013 Pharmacogenetics is considered as a prime example of how personalized medicine nowadays can be put into practice. However, genotyping to guide pharmacological treatment is relatively uncommon in the routine clinical practice. Several reasons can be found
De Paepe, Anne, Vanakker, Olivier
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Turkish Journal of Hematology, 2014 Myelosuppression is a serious complication during treatment of acute lymphoblastic leukemia and the duration of myelosuppression is affected by underlying bone marrow failure syndromes and drug pharmacogenetics caused by genetic polymorphisms.
Burcu Fatma Belen +5 more
doaj +1 more source
Proteomic changes in rat hippocampus and adrenals following short-term sleep deprivation [PDF]
, 2008 peer reviewedABSTRACT: BACKGROUND: To identify the biochemical changes induced by sleep deprivation at a proteomic level, we compared the hippocampal proteome of rats either after 4 hours of sleep or sleep deprivation obtained by gentle handling. Because
Jean-Etienne Poirrier +6 more
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Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism. [PDF]
Basic Clin Pharmacol Toxicol, 2021 Zimdahl Kahlin A +5 more
europepmc +1 more source
Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children. [PDF]
, 2016 Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to ...
Dale, Rc, Lim, M., Nosadini, M
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Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]
, 2012 The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
Abboudi, H, Macphee, IA
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A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol [PDF]
, 2014 BACKGROUND: BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased sensitivity to cisplatin and poly (
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