Results 101 to 110 of about 6,220 (214)

Individualized therapy: Role of thiopurine S-methyltransferase protein and genetic variants [PDF]

Journal of Medical Biochemistry, 2010
Thiopurine S-methyltransferase (TPMT: EC 2.1.1.67) is an enzyme that metabolizes immunosuppressive thiopurine medications, used in the treatment of autoimmune diseases, cancer and in transplantation medicine.
Pavlović Sonja, Zukić Branka
doaj  

Common Polymorphism’s Analysis of Thiopurine S-Methyltransferase (TPMT) in Iranian Population [PDF]

Cell Journal, 2009
Objective: Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurinedrugs. Low activity phenotypes are correlated with several mutations in the TPMTgene and adverse drug reactions.
Mehdi Azad, Saeid Kaviani, Masoud Soleimani, Mehrdad Noruzinia, Abbas Hajfathali   +4 more
doaj  

A drug‐repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6‐thioguanine as an effective therapeutic agent for TPMT‐low cancer cells

Molecular Oncology, 2018
Pancreatic cancer is one of the most difficult cancers to cure due to the lack of early diagnostic tools and effective therapeutic agents. In this study, we aimed to isolate new bioactive compounds that effectively kill pancreatic ductal adenocarcinoma ...
Inki Kim, Yeon‐Sook Choi, Jae Hwi Song, Eun A Choi, Sojung Park, Eun Ji Lee, Je‐Keun Rhee, Song Cheol Kim, Suhwan Chang   +8 more
doaj   +1 more source

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes [PDF]

, 2018
Rifampin is a pleiotropic inducer of multiple drug metabolizing enzymes and transporters. This work utilized a global approach to evaluate rifampin effects on conjugating enzyme gene expression with relevance to human xeno- and endo-biotic metabolism ...
Desta, Zeruesenay, Eadon, Michael T., Gao, Hongyu, Gufford, Brandon T., Lin, Hai, Liu, Yunlong, Robarge, Jason D., Skaar, Todd C.   +7 more
core   +1 more source

Current Status of Autoimmune Hepatitis in Japan [PDF]

, 2008
Autoimmune hepatitis (AIH) is a chronic and progressive disease characterized by histological interface hepatitis, hypergammaglobulinemia, and circulating autoantibodies. Multiple factors, including molecular mimicry, a genetic background including major
Miyake, Yasuhiro, Yamamoto, Kazuhide
core   +1 more source

Thiopurines inhibit bovine viral diarrhea virus production in a thiopurine methyltransferase-dependent manner

Journal of General Virology, 2008
The family Flaviviridae comprises positive-strand RNA viral pathogens of humans and livestock with few treatment options. We have previously shown that azathioprine (AZA) has in vitro activity against bovine viral diarrhea virus (BVDV). While the mechanism of inhibition is unknown, AZA and related thiopurine nucleoside analogues have been used as ...
Spencer, Hoover, Rob, Striker
openaire   +2 more sources

A Practical Non-Extraction Direct Liquid Chromatography Method for Determination of Thiopurine S-Methyltransferase Activity in Inflammatory Bowel Disease

Acta Medica Iranica, 2017
Thiopurine drugs remain pivotal therapies for the wide varieties of diseases such as inflammatory bowel disease (IBD). Here, thiopurine S-methyltransferase (TPMT) phenotype, the main metabolizing enzyme of thiopurine-drugs, was studied.
Fariborz Bahrehmand, Amir Kiani, Asad Vaisi-Raygani, Homayoun Bashiri, Mehdi Zobeiri, Ali Moini, Tayebeh Pourmotabbed   +6 more
doaj  

Population-Specific Distribution of TPMT Deficiency Variants and Ancestry Proportions in Ecuadorian Ethnic Groups: Towards Personalized Medicine

Therapeutics and Clinical Risk Management, 2023
Jennifer Gallardo-Cóndor,1 Pablo Naranjo,1 Sebastián Atarihuana,1 Dayana Coello,2 Patricia Guevara-Ramírez,3 Rodrigo Flores-Espinoza,4 Germán Burgos,5,6 Andrés López-Cortés,7,8 Alejandro Cabrera-Andrade9,10 1Facultad de Ingeniería y Ciencias Aplicadas ...
Gallardo-Cóndor J, Naranjo P, Atarihuana S, Coello D, Guevara-Ramírez P, Flores-Espinoza R, Burgos G, López-Cortés A, Cabrera-Andrade A   +8 more
doaj  

Sequential group trial to determine gastrointestinal site of absorption and systemic exposure of azathioprine [PDF]

, 2000
Azathioprine (AZA) is used in the treatment of patients with refractory inflammatory bowel disease; however, its use is limited because of systemic toxicity associated with long-term use.
Abell, Thomas, Brown, Rex O., Gervasio, Jane M., Haberer, Lynda J., Hak, Lawrence J., Lima, John, Tabbaa, M. G., Werkman, Robert   +7 more
core   +1 more source

Normal Ranges of Thiopurine Methyltransferase Activity Do Not Affect Thioguanine Nucleotide Concentrations With Azathioprine Therapy in Inflammatory Bowel Disease. [PDF]

Crohns Colitis 360, 2020
Jonason DE, Sievers T, Trocke L, Abraham JM, Vaughn BP.   +4 more
europepmc   +1 more source