Results 121 to 130 of about 6,220 (214)

Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait. [PDF]

Clin Pharmacol Ther, 2017
Liu C, Yang W, Pei D, Cheng C, Smith C, Landier W, Hageman L, Chen Y, Yang JJ, Crews KR, Kornegay N, Karol SE, Wong FL, Jeha S, Sandlund JT, Ribeiro RC, Rubnitz JE, Metzger ML, Pui CH, Evans WE, Bhatia S, Relling MV.   +21 more
europepmc   +1 more source

Farmakogenetiikka saapuu klinikkaan [PDF]

, 2016
English summaryPeer ...
Elenius, Klaus, Elenius, Varpu, Heliste, Juho, Niemi, Mikko   +3 more
core  

[Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites].

Anales de pediatria (Barcelona, Spain : 2003), 2009
Individualised doses of azathioprine (AZA) may be prescribed by monitoring the levels of the enzyme thiopurine methyltransferase (TPMT). The measurements of thiopurine metabolites of AZA, 6-thioguanine (6-TGN) and 6-methylmercaptopurine (6-MMP), have also been reported as new markers of AZA activity.To describe TPMT phenotype in our population and to ...
M, Alvarez Beltran, D, Infante Pina, R, Tormo Carnicé, O, Segarra Cantón, S, Redecillas Ferreiro   +4 more
openaire   +1 more source

Identification of cellular proteome using two-dimensional difference gel electrophoresis in ST cells infected with transmissible gastroenteritis coronavirus [PDF]

, 2013

core   +1 more source

Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity. [PDF]

Cancer Chemother Pharmacol, 2017
Liu C, Janke LJ, Yang JJ, Evans WE, Schuetz JD, Relling MV.   +5 more
europepmc   +1 more source

Integration of a standardized pharmacogenomic platform for clinical decision support at Boston Children's Hospital [PDF]

, 2012
Brownstein, Catherine A., Clinton, Catherine, Fusaro, Vincent Alfred, Mandl, Kenneth David, Manzi, Shannon, Margulies, David Michael, Savage, Sarah, Wolf, Wendy   +7 more
core   +1 more source

Frequency of thiopurine methyltransferase variants and exploratory predictors of azathioprine-induced leukopenia in Saudi patients with inflammatory bowel disease. [PDF]

Saudi J Gastroenterol
Meeralam YK, Al-Zanbagi AB, Al Saedi M, Sulaimani M, Basfar A, Almutawa W, Albelewi SH, Shariff MK.   +7 more
europepmc   +1 more source

Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study. [PDF]

PLoS One, 2018
Hessels AC, Rutgers A, Sanders JSF, Stegeman CA.   +3 more
europepmc   +1 more source

Thiopurine methyltransferase genotype and thiopurine S-methyltransferase activity in Greek children with inflammatory bowel disease.

Annals of gastroenterology
Azathioprine (AZA) and 6-mercaptopurine (6MP) are used in the treatment of pediatric inflammatory bowel disease (IBD). Genetic variations in thiopurine S-methyltranfarase (TPMT) gene have been correlated with enzyme activity and with the occurrence of adverse events to AZA and 6MP.
Muaria, Gazouli, Ioanna, Pachoula, Ioanna, Panayotou, Georgios, Chouliaras, Nicholas P, Anagnou, George, Chroussos, Eleftheria, Roma   +6 more
openaire   +1 more source

Thiopurine methyltransferase and treatment outcome in the UK acute lymphoblastic leukaemia trial ALL2003. [PDF]

Br J Haematol, 2015
Lennard L, Cartwright CS, Wade R, Vora A.   +3 more
europepmc   +1 more source