Identifikasi Gen Selenometil Transferase (Smt) Pada Isolat Geobacillus SP. 20k Yang Resisten Terhadap Selenium [Identification of Seleno Methyltransferase {Smt) Gene From Geobacillus SP. 20k Resistant to Selenium] [PDF]
, 2010 The trace element Selenium is toxic at high concentration.Most of organisms living in selenium rich environment are selenium resistant.One of the resistance mechanisms is methylation,in which selenium is methylated and transformed to non-toxic selenium ...
Dewi, R. M. (Ratih) +4 more
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Personalised medicine, unmet need or business strategy?
, 2013 Personalised medicine is a discipline that integrates pharmaceutical development with existing knowledge about the genetic and phenotypic factors that influence drug response.
Sáinz de la Fuente, G. (Graciela)
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UEG Week 2025 Moderated Posters
United European Gastroenterology Journal, Volume 13, Issue S8, Page S189-S802, October 2025.
wiley +1 more source
Development of a Scalable Pharmacogenomic Clinical Decision Support Service [PDF]
, 2014 Advances in sequencing technology are making genomic data more accessible within the healthcare environment. Published pharmacogenetic guidelines attempt to provide a clinical context for specific genomic variants; however, the actual implementation to ...
Brownstein, Catherine +7 more
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Genetic Polymorphism of Thiopurine S-Methyltransferase in Children with Acute Lymphoblastic Leukemia
Pakistan Journal of Medicine and DentistryBackground: 6-Mercaptopurine (6-MP), a widely used anti-metabolite for the maintenance phase of childhood acute lymphoblastic leukemia (ALL), has been observed to cause myelotoxicity due to genetic polymorphism of thiopurine methyl transferase (TPMT ...
Afrina Raza +3 more
doaj +1 more source
Thiopurine methyltransferase activity in children with acute myeloid leukemia. [PDF]
Oncol Lett, 2018 Sobiak J +6 more
europepmc +1 more source
Pharmacogenetic studies of thiopurines : focus on thiopurine methyltransferase
, 2005 Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect. Thiopurines are used in inflammatory bowel disease, as maintenance treatment of childhood acute lymphoblastic leukaemia ...
openaire +1 more source
Biomedicine & PharmacotherapyUnderstanding the molecular mechanisms of medicines is crucial for developing novel drugs, for repurposing existing medicines, and for predicting toxicities. Thiopurine S-methyltransferase (TPMT) serves as an exemplary case in personalized medicine, as its activity is influenced by genetic variants, co-factors, substrates, and inhibitors, which lead to
Dunja Urbančič +5 more
openaire +2 more sources
Utilizing a user-centered approach to develop and assess pharmacogenomic clinical decision support for thiopurine methyltransferase. [PDF]
BMC Med Inform Decis Mak, 2019 Nguyen KA +6 more
europepmc +1 more source
Immunotherapy in childhood B-cell acute lymphoblastic leukemia [PDF]
, 2018 Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2018.Cataloged from PDF version of thesis.Includes bibliographical references (pages 18-21).B-cell acute lymphoblastic leukemia is the most common pediatric cancer, responsible ...
Besada, Rana Hany
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