Results 81 to 90 of about 206,003 (304)

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Insights into the Specificity of Thioredoxin Reductase−Thioredoxin Interactions. A Structural and Functional Investigation of the Yeast Thioredoxin System

, 2016
The enzymatic activity of thioredoxin reductase enzymes is endowed by at least two redox centers: a flavin and a dithiol/disulfide CXXC motif. The interaction between thioredoxin reductase and thioredoxin is generally species-specific, but the molecular ...
Francisco J. Medrano (2119840), Beatriz G. Guimarães (2304772), Luis E. S. Netto (127450), Marcos A. Oliveira (2304778), Karen F. Discola (2304781), Simone V. Alves (2304775)   +5 more
core   +1 more source

Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast [PDF]

, 2009
Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. To investigate the role of thioredoxin in controlling p53 activity, the level of reporter gene transactivation by p53 was ...
Stoner, Christopher S., Pearson, George D., Lopez, Nathan I., Merrill, Gary Frederic, Merwin, Jason R., Koç, Ahmet   +5 more
core   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Functional Improvement of Human Cardiotrophin 1 Produced in Tobacco Chloroplasts by Co-Expression with Plastid Thioredoxin m

Plants, 2020
Human cardiotrophin 1 (CT1), a cytokine with excellent therapeutic potential, was previously expressed in tobacco chloroplasts. However, the growth conditions required to reach the highest expression levels resulted in an impairment of its bioactivity ...
María Ancín, Ruth Sanz-Barrio, Eva Santamaría, Alicia Fernández-San Millán, Luis Larraya, Jon Veramendi, Inmaculada Farran   +6 more
doaj   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Thioredoxin-1 in Alzheimer disease

, 2015
Oxidative stress is one of the earliest signs in Alzheimer Disease (AD) brain. In order to protect themselves against oxidative stress, neurons use antioxidants as a defense mechanism. Such an antioxidant is Thioredoxin-1 (Trx1).
Torbjörn Persson (18671686)
core  

Western blots of cytosolic Thioredoxin and Thioredoxin reductase.

, 2016
Representative western blots used for the protein estimations of cytosolic thioredoxin (A) and cytosolic thioredoxin reductase (B).
Galina Zeltcer (2890028), Mordechai Chevion (119370), Benjamin Drenger (2890031), Hilbert Grievink (2890025), Eduard Berenshtein (119363)   +4 more
core   +1 more source

Liebig Review: Essential and Beneficial Elements in the Regulation of Cadmium Uptake and Tolerance in Crop Plants

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Cadmium (Cd2+) contamination in agricultural soils has been reported to pose risks to crop productivity, food safety, and human health. This review synthesizes current knowledge on the mechanisms by which essential (S, Zn, Fe, Mg, K, Ca) and beneficial (Si, Se, rare earth elements) elements mitigate Cd2+ toxicity in plants.
Maria Manzoor, Karl Hermann Mühling
wiley   +1 more source

A Toxoplasma gondii thioredoxin with cell adhesion and antioxidant function

Frontiers in Cellular and Infection Microbiology
BackgroundToxoplasma gondii (T. gondii) is a widespread, zoonotic protozoan intracellular parasite with a complex life cycle, which can cause toxoplasmosis, a potentially serious disease. During the invasion process, T.
Dawei Wang, Dawei Wang, Yuyi Shi, Yuyi Shi, Ziwen Cheng, Ziwen Cheng, Like Luo, Like Luo, Kuo Cheng, Kuo Cheng, Shengqi Gan, Shengqi Gan, Che Liu, Che Liu, Zeliang Chen, Baoling Yang, Baoling Yang   +16 more
doaj   +1 more source