Results 221 to 230 of about 31,059 (323)

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?

Aging Cell, Volume 25, Issue 2, February 2026.
This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan, Simon Reinhard, Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh, James F. Collins, Stephen D. Anton   +6 more
wiley   +1 more source

Thioredoxin System in Insects: Uncovering the Roles of Thioredoxins and Thioredoxin Reductase beyond the Antioxidant Defences. [PDF]

Insects
Gřešková A, Petřivalský M.
europepmc   +1 more source

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

Andrology, Volume 14, Issue 2, Page 496-515, February 2026.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma   +8 more
wiley   +1 more source

Redox metabolism and signalling in plants. [PDF]

J Exp Bot
Boscari A, Frendo P.
europepmc   +1 more source

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

The FEBS Journal, Volume 293, Issue 3, Page 749-765, February 2026.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner, Deniz Tümen, Arne Kandulski, Philipp Heumann, Patricia Mester, Elisabeth Aschenbrenner, Kirstin Pollinger, Manuela Gunckel, Barbara Volz, Tobias Hein, Paul L. Beltzig, Luisa Tengler, Florian Voll, Marina Kreutz, Claudia Kunst, Jan P. Nicolay, Martina Müller, Karsten Gülow   +17 more
wiley   +1 more source

Thioredoxin 1 moonlights as a chaperone for an interbacterial ADP-ribosyltransferase toxin. [PDF]

Nat Commun
Dumont B, Terradot L, Cascales E, Van Melderen L, Jurėnas D.   +4 more
europepmc   +1 more source

The Subgingival Host–Microbial Landscape in Mothers With Periodontitis and Their At‐Risk Offspring

Journal of Clinical Periodontology, Volume 53, Issue 2, Page 201-213, February 2026.
ABSTRACT Aim To evaluate the subgingival proteome and microbiome of mothers with periodontitis and their offspring, thereby assessing signatures of periodontal diseases. Methods Forty participants in four groups were included: mothers with periodontitis and their offspring, as well as periodontally healthy mothers and their offspring.
Hélvis E. S. Paz, Camila S. Stolf, Kai Bao, Mabelle F. Monteiro, Lucas M. Carvalho, Angelika Silbereisen, Georgios N. Belibasakis, Renato C. V. Casarin, Nagihan Bostanci   +8 more
wiley   +1 more source

Dynamic regulation of Arabidopsis β-AMYLASE1 by glutathione and thioredoxins affects starch in guard cells. [PDF]

Plant Physiol
Gurrieri L, Capuzzi AC, Müller-Schüssele SJ, Trost P, Sparla F.   +4 more
europepmc   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, Volume 301, Issue 2, Page 122-150, February 2026.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Intact Proteoform Analysis by Capillary Electrophoresis–Mass Spectrometry. Are We There Yet?

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Mass spectrometry (MS) and top–down proteomics (TDP) have emerged as powerful tools to decipher proteoform‐level information, advancing biological insight and translational research. This study unites leaders in capillary electrophoresis (CE) and MS from multiple institutions across the globe to showcase the reproducibility, unique information, and ...
Noah Gould, Qianjie Wang, Jeffrey N. Agar, Jennifer S. Brodbelt, Daoyang Chen, Kellye A. Cupp‐Sutton, Elena Domínguez‐Vega, Fei Fang, Marianne Fillet, Matthew S Fischer, Attila Gaspar, Ying Ge, Marie‐Jia Gou, Michal Greguš, Christoph Gstöttner, Narmin Hamidli, Amanda Helms, Md Amin Hossain, Kyle J. Juetten, Neil L. Kelleher, Tobias Kraus, Eli J. Larson, J. Scott Mellors, Cynthia Nagy, Christian Neusüß, Erin A. Redman, Jasmin Schairer, Si Wu, Tian Xu, Zhitao Zhao, Guijie Zhu, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +33 more
wiley   +2 more sources