Results 161 to 170 of about 2,737 (218)
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Journal of Cardiovascular Pharmacology, 1989
To evaluate the role of endopeptidase 24.11 in metabolism of atrial natriuretic peptide (ANP) in vivo, we examined the effect of thiorphan, an inhibitor of this enzyme, on plasma ANP concentrations and the cardiovascular and renal actions of ANP(99-126).
A. Trapani +6 more
semanticscholar +3 more sources
To evaluate the role of endopeptidase 24.11 in metabolism of atrial natriuretic peptide (ANP) in vivo, we examined the effect of thiorphan, an inhibitor of this enzyme, on plasma ANP concentrations and the cardiovascular and renal actions of ANP(99-126).
A. Trapani +6 more
semanticscholar +3 more sources
Potentiation of stress-induced analgesia (SIA) by thiorphan and its block by naloxone.
Life Sciences, 1982Exposure of rats to inescapable footshock produces an analgesic effect. To determine if endogenously released enkephalins play a role in this phenomenom, rats were treated with the enkephalinase inhibitor thiorphan (T), exposed to inescapable stress, and tested in the tail-flick test for antinociception.
R. Chipkin, M. Latranyi, L. Iorio
semanticscholar +3 more sources
Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins.
European Journal of Pharmacology, 1989Tachykinins produced a concentration-related contraction of the isolated guinea-pig gallbladder, with a rank order of potency neurokinin A (NKA) greater than Arg-neurokinin B = neurokinin B (NKB) greater than substance P (SP). Only the effect of SP was potentiated by thiorphan (0.1-10 microM).
C. Maggi +8 more
semanticscholar +4 more sources
Neuroscience Letters, 2003
Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid beta (Abeta) may not be the only pathogenic route to AD. Decreased degradation of Abeta is another possible disease mechanism. Neprilysin is a neutral endopeptidase that has been proposed to be the major enzyme responsible for Abeta degradation.
Amanda Newell +6 more
semanticscholar +3 more sources
Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid beta (Abeta) may not be the only pathogenic route to AD. Decreased degradation of Abeta is another possible disease mechanism. Neprilysin is a neutral endopeptidase that has been proposed to be the major enzyme responsible for Abeta degradation.
Amanda Newell +6 more
semanticscholar +3 more sources
Journal of Biochemistry, 2001
The effects of the metalloproteinase inhibitors thiorphan and R-94138 on the matrilysin-catalyzed hydrolysis of (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N(3)-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-L-Ala-L-Arg-NH(2) [MOCAc-PLGL(Dpa)AR] were examined.
H. Oneda, K. Inouye
semanticscholar +3 more sources
The effects of the metalloproteinase inhibitors thiorphan and R-94138 on the matrilysin-catalyzed hydrolysis of (7-methoxycoumarin-4-yl)acetyl-L-Pro-L-Leu-Gly-L-Leu-[N(3)-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-L-Ala-L-Arg-NH(2) [MOCAc-PLGL(Dpa)AR] were examined.
H. Oneda, K. Inouye
semanticscholar +3 more sources
Fundamental & Clinical Pharmacology, 2023
The combined angiotensin receptor neprilysin inhibitor is a promising cardioprotective pharmacological agent. This study investigated the beneficial effects of thiorphan (TH)/irbesartan (IRB), in myocardial ischemia–reperfusion (IR) injury, compared to ...
Takwa Mohammed Abdulsalam +6 more
semanticscholar +1 more source
The combined angiotensin receptor neprilysin inhibitor is a promising cardioprotective pharmacological agent. This study investigated the beneficial effects of thiorphan (TH)/irbesartan (IRB), in myocardial ischemia–reperfusion (IR) injury, compared to ...
Takwa Mohammed Abdulsalam +6 more
semanticscholar +1 more source
Thiorphan has neuroprotective effects
Nature Clinical Practice Neurology, 2007 openalex +2 more sources
Soluble rabbit neprilysin in complex with thiorphan
, 2018 S. Labiuk, P. Grochulski, J. Sygusch
semanticscholar +2 more sources
Bioorganic & Medicinal Chemistry Letters, 1992
Abstract Syntheses and biological activities of four thiorphan isosteres or analogs are described. The central amide linkage is replaced by ketomethylene, aminomethylene, thioamide, and trans-olefinic functionalities. Double chelation mechanism for the inhibitor-enkephalinase docking process is proposed.
Monteil Thierry +7 more
openaire +1 more source
Abstract Syntheses and biological activities of four thiorphan isosteres or analogs are described. The central amide linkage is replaced by ketomethylene, aminomethylene, thioamide, and trans-olefinic functionalities. Double chelation mechanism for the inhibitor-enkephalinase docking process is proposed.
Monteil Thierry +7 more
openaire +1 more source