Results 161 to 170 of about 2,711 (217)
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Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5] enkephalin.
European Journal of Pharmacology, 1982The intrathecal administration of thiorphan (dl-3-mercapto-2-benzylpropranoyl-glycine) had no effect in doses up to 70 microgram on the rat hot plate and tail flick. Administrations of these doses of thiorphan concurrently or up to 1 h prior to the intrathecal administration of [D-Ala2, Met5] enkephalin resulted in a dose dependent, leftward shift in ...
T. Yaksh, G. Harty
semanticscholar +4 more sources
Optimization of retro-thiorphan for inhibition of endothelin converting enzyme
Bioorganic & Medicinal Chemistry Letters, 1996Abstract The structural requirements of retro-thiorphan, N -[1 R , S -benzyl-2-mercaptoethyl]malonamic acid 2 , analogs for the inhibition of endothelin converting enzyme (ECE) were investigated. Although based on a single amino acid residue, N -[1 R -(1 H -indol-3-ylmethyl)-2-mercaptoethyl]-2-phenylacetamide 28 was found to be two times more ...
W.X. Kozak +4 more
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The effect of inhaled thiorphan on allergen‐induced airway responses in asthmatic subjects
Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, 1996 SummaryBackground Neuropeptides are likely to be implicated in the pathophysiology of allergen‐induced airway responses. However, upon release in the airways, neuropeptides are potentially inactivated by neutral endopeptidase (NEP). Objective We hypothesized that NEP‐inhibition by inhaled thiorphan (TH) would increase allergen‐induced early (EAR)
Zuzana Diamant +4 more
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Behavioral Neuroscience, 1984
Opiates are known to be reinforcing when injected into the ventral tegmental area (VTA). The present study produced conditioned reinforcement with local injections of exogenous d-ala2-met5-enkephalinamide (DALA), a potent analogue of met-enkephalin, and with thiorphan , an enkephalinase inhibitor which protects endogenous opiates from enzymic ...
P. Glimcher +3 more
semanticscholar +4 more sources
Opiates are known to be reinforcing when injected into the ventral tegmental area (VTA). The present study produced conditioned reinforcement with local injections of exogenous d-ala2-met5-enkephalinamide (DALA), a potent analogue of met-enkephalin, and with thiorphan , an enkephalinase inhibitor which protects endogenous opiates from enzymic ...
P. Glimcher +3 more
semanticscholar +4 more sources
Potentiation of stress-induced analgesia (SIA) by thiorphan and its block by naloxone.
Life Sciences, 1982Exposure of rats to inescapable footshock produces an analgesic effect. To determine if endogenously released enkephalins play a role in this phenomenom, rats were treated with the enkephalinase inhibitor thiorphan (T), exposed to inescapable stress, and tested in the tail-flick test for antinociception.
R. Chipkin, M. Latranyi, L. Iorio
semanticscholar +4 more sources
Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins
European Journal of Pharmacology, 1989Tachykinins produced a concentration-related contraction of the isolated guinea-pig gallbladder, with a rank order of potency neurokinin A (NKA) greater than Arg-neurokinin B = neurokinin B (NKB) greater than substance P (SP). Only the effect of SP was potentiated by thiorphan (0.1-10 microM).
C. A. Maggi +8 more
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Journal of Pharmacology and Experimental Therapeutics, 1987 Bruno Giros +9 more
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Potentiation of the hypoglycemic effect of insulin by thiorphan, an enkephalinase inhibitor
European Journal of Pharmacology, 1984Insulin administration to rats produced a dose-related hypoglycemia. When insulin and the enkephalinase (Enk'ase) inhibitor thiorphan (30 or 100 mg/kg s.c.) were co-administered, there was a potentiation of the hypoglycemic response to insulin; these doses of thiorphan alone had no significant effect on plasma glucose.
Richard E. Chipkin +2 more
openaire +3 more sources