Results 171 to 180 of about 2,059 (202)

ChemInform Abstract: Synthesis of Constrained Thiorphan Analogues as Inhibitors of Neutral Endopeptidase.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
D. W. BEIGHT, S. MEHDI, J. R. KOEHL, G. A. FLYNN   +3 more
openaire   +1 more source

Thiorphan-induced neprilysin inhibition raises amyloid β levels in rabbit cortex and cerebrospinal fluid

Neuroscience Letters, 2003
Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid beta (Abeta) may not be the only pathogenic route to AD. Decreased degradation of Abeta is another possible disease mechanism. Neprilysin is a neutral endopeptidase that has been proposed to be the major enzyme responsible for Abeta degradation.
Amanda J, Newell, Lucia I, Sue, Sarah, Scott, Paula K, Rauschkolb, Douglas G, Walker, Pamela E, Potter, Thomas G, Beach   +6 more
openaire   +2 more sources

Contribution of ANP to plasma protein escape during VE: effects of thiorphan and atrial appendectomy

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1996
The effects of endopeptidase inhibition and right atrial appendectomy (AA) on plasma immunoreactive atrial natriuretic peptide (irANP) concentrations and extravascular accumulation of 131I-labeled bovine serum albumin (CBSA) during volume expansion (VE) were examined in pentobarbital sodium-anesthetized rats (n = 5 per group).
openaire   +2 more sources

Effects of inhaled or intravenous thiorphan on substance P-induced airway obstruction.

Agents and actions. Supplements, 1992
Male Hartley guinea pigs were treated with the enkephalinase inhibitor thiorphan by inhaled or intravenous administration routes and potentiation of substance P-induced airway obstruction examined. Inhaled thiorphan was several thousand times more potent than intravenous thiorphan.
S A, Silbaugh, S L, Cockerham, P W, Stengel   +2 more
openaire   +1 more source

Thiorphan

2007
S.J. Enna, David B. Bylund
openaire   +1 more source

Effects of thiorphan, bestatin and captopril on the Lewis lung carcinoma metastases in mice.

Polish journal of pharmacology, 1996
Previously we have found that administration of thiorphan alone or in combination with bestatin exerts antitumor effect in mice, including reduction of B16 melanoma tumor growth and prolongation of survival time. These data prompted us to extend our studies to estimate the effect of treatment with thiorphan, captopril and bestatin on lung metastases in
J, Kowalski, D, Belowski, A, Madej, Z S, Herman   +3 more
openaire   +1 more source

Thiorphan has neuroprotective effects

Nature Clinical Practice Neurology, 2007
openaire   +1 more source

Neutral endopeptidase (NEP) inhibitors – thiorphan, sialorphin, and its derivatives exert anti-proliferative activity towards colorectal cancer cells in vitro

, 2019
Magdalena Mizerska-Kowalska, Joanna Kreczko–Kurzawa, Barbara Zdzisińska, Arkadiusz Czerwonka, Adrianna Sławińska-Brych, Zbigniew Maćkiewicz, Dawid Nidzworski, Martyna Kandefer‐Szerszeń   +7 more
openalex   +1 more source

Inhibitory potencies of UK-69 578 and thiorphan

The Lancet, 1990
openaire   +1 more source

Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects

, 1994
Zuzana Diamant, M C Timmers, H. van der Veen, Patrick Booms, Jacob K. Sont, PJ Sterk   +5 more
openalex   +1 more source