Results 181 to 190 of about 2,711 (217)
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Thiorphan and acetorphan inhibit gastric secretion by a central, non-opioid mechanism in the rat
European Journal of Pharmacology, 1988Thiorphan and its prodrug, acetorphan, are two inhibitors of enkephalinase (EC 3.4.24.11), a membrane-bound peptidase which plays an important role in the metabolic degradation of enkephalins. Since exogenous opioids have been reported to both stimulate and inhibit gastric secretion, the effects of thiorphan and acetorphan were studied in conscious ...
Claude Rozé +5 more
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Haematologia, 2000 Thiorphan [(DL-3-mercapto-2-benzylpropanoyl)-glycine], a drug blocking the activity of membrane metalloendopeptidase EC 3.4.24.11 (CD10, CALLA), was added to long-term cultures of human bone marrow. Progression of the cultures was assessed by cell counts, cytology and clonogenic (GM-CFU) ability of the non-adherent cells in the supernatant and by ...
S Janda +6 more
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Antitumor activity of bestatin and thiorphan in mice.
Archivum immunologiae et therapiae experimentalis, 1996We have investigated the effect of bestatin and thiorphan on growth of murine transplantable tumors, survival time, activity of natural killer (NK) cells and macrophages in mice. The injections of thiorphan at the does of 0.5 or 5 micrograms per mouse retarded tumor growth and prolonged survival period in B16 melanoma bearing animals. Pretreatment with
J, Kowalski +3 more
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Brain Research, 1986
The endogenous opioid peptide enkephalin (EK) is known to be degraded mainly by two enzymes, the dipeptidyl carboxypeptidase 'enkephalinase' and aminopeptidase. Microinjection of the enkephalinase inhibitor thiorphan or the aminopeptidase inhibitor bestatin into the nucleus accumbens of the rabbit produced a dose-dependent analgesic effect.
Ji-Sheng Han +2 more
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The endogenous opioid peptide enkephalin (EK) is known to be degraded mainly by two enzymes, the dipeptidyl carboxypeptidase 'enkephalinase' and aminopeptidase. Microinjection of the enkephalinase inhibitor thiorphan or the aminopeptidase inhibitor bestatin into the nucleus accumbens of the rabbit produced a dose-dependent analgesic effect.
Ji-Sheng Han +2 more
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Contribution of ANP to plasma protein escape during VE: effects of thiorphan and atrial appendectomy
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1996The effects of endopeptidase inhibition and right atrial appendectomy (AA) on plasma immunoreactive atrial natriuretic peptide (irANP) concentrations and extravascular accumulation of 131I-labeled bovine serum albumin (CBSA) during volume expansion (VE) were examined in pentobarbital sodium-anesthetized rats (n = 5 per group).
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Substance P-induced effects in guinea pig lungs: effects of thiorphan and captopril
Journal of Applied Physiology, 1989The effects of the neutral metalloendopeptidase inhibitor, thiorphan, and the angiotensin-converting enzyme inhibitor, captopril, on the changes in airway opening pressure (PaO), pulmonary arterial pressure (Ppa), and weight induced by intravascular administration of substance P were examined in isolated perfused and ventilated guinea pig lungs ...
Jeffrey M. Drazen +2 more
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European Journal of Pharmacology, 2020
Takwa Mohammed Abdulsalam +3 more
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Takwa Mohammed Abdulsalam +3 more
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Effects of thiorphan, bestatin and captopril on the Lewis lung carcinoma metastases in mice.
Polish journal of pharmacology, 1996Previously we have found that administration of thiorphan alone or in combination with bestatin exerts antitumor effect in mice, including reduction of B16 melanoma tumor growth and prolongation of survival time. These data prompted us to extend our studies to estimate the effect of treatment with thiorphan, captopril and bestatin on lung metastases in
J, Kowalski +3 more
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Inhibitory potencies of UK-69 578 and thiorphan
The Lancet, 1990G.M.R. Samuels +2 more
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