Bacterial Isothiocyanate Biosynthesis by Rhodanese‐Catalyzed Sulfur Transfer onto Isonitriles
A novel biosynthetic pathway towards isothiocyanate natural products is identified. In vivo and in vitro biotransformation show that rhodanese‐like proteins (Rhd), known for the detoxification of cyanide, have been recruited and neofunctionalized to catalyze sulfur incorporation into isonitriles in bacteria.
Mandy D. Mlotek +2 more
wiley +1 more source
Thiosulfate sulfurtransferase and UDP-glucuronosyltransferase activities in cholestatic rat liver induced by common bile duct ligation [PDF]
We have investigated the effect of cholestasis on the hepatic thiosulfate sulfurtransferase (rhodanese) and UDP-glucuronosyltransferase (UDP-GT) activities in rats. Rhodanese activities in the liver cytosol, mitochondria and microsomal fractions as well as in the rat serum, and UDP-GT activity in the microsome have been investigated for a period of 42 ...
Jong-Sool Ihm, You-Hee Kim
openaire +2 more sources
Advances in Gas Therapeutics for Wound Healing: Mechanisms, Delivery Materials, and Prospects
Therapeutic gases, such as oxygen, nitric oxide, carbon monoxide, and hydrogen sulfide, have transitioned from pure gases to inorganic/organic materials as gas‐releasing materials, including gas‐producing and gas‐loaded materials and controlled/long‐lasting stable‐releasing biomaterials for biomedical application in wound healing.
Jiayi Ding +5 more
wiley +1 more source
Background The hepatoprotective potential of Phellinus linteus polysaccharide (PLP) extracts has been described. However, the molecular mechanism of PLP for the inhibition of liver fibrosis is unclear. This study aims to investigate the molecular protein
Wang Hualin +6 more
doaj +1 more source
Genome sequence of Desulfurella amilsii strain TR1 and comparative genomics of Desulfurellaceae family [PDF]
The acidotolerant sulfur reducer Desulfurella amilsii was isolated from sediments of Tinto river, an extremely acidic environment. Its ability to grow in a broad range of pH and to tolerate certain heavy metals offers potential for metal recovery ...
Ahemad +63 more
core +3 more sources
This study was undertaken to investigate the relationships between stage of embryonic development and early posthatch growth and the level of rhodanese (thiosulfate:cyanide sulfurtransferase) activity in different regions of the digestive tract and liver of chickens. The embryos were studied at 14, 17, and 20 d and chickens were 1, 2, and 3 wk old. All
M, Aminlari +3 more
openaire +2 more sources
Isolation of Cyanide Hydratase Mutants from Gloeocerospora Sorghi at alkaline pH [PDF]
Cyanide is both a useful and dangerous chemical compound that serves as a crucial component in multiple industrial processes, including metal mining.
Lessen, Henry Joseph
core +1 more source
Catalase as a sulfide-sulfur oxido-reductase: An ancient (and modern?) regulator of reactive sulfur species (RSS) [PDF]
Catalase is well-known as an antioxidant dismutating H2O2 to O2 and H2O. However, catalases evolved when metabolism was largely sulfur-based, long before O2 and reactive oxygen species (ROS) became abundant, suggesting catalase metabolizes reactive ...
Arif, Faihaan +6 more
core +2 more sources
Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that occur concurrently and increase the risk of cardiovascular disease. 3-mercaptopyruvate sulfurtransferase (MPST) is a cysteine-catabolizing enzyme that yields pyruvate and hydrogen ...
Paraskevas Zampas +7 more
doaj +1 more source
A critical role for cystathionine-β-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery [PDF]
Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated.
Alexander, Stephen P.H. +6 more
core +2 more sources

