Results 181 to 190 of about 51,903 (296)

Enantioselective cyclization reactions involving 3-isothiocyanato oxindoles: synthesis of spirocycles. [PDF]

RSC Adv
Edareh MH, Doraghi F, Farahani A, Ghasemi M, Mahdavi M.   +4 more
europepmc   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

Cylindrospermopsin toxicokinetics: in silico ADMET modeling, rat and human liver microsome metabolism, and UHPLC-MS/MS metabolite characterization. [PDF]

Arch Toxicol
Cascajosa-Lira A, Guzmán-Guillén R, Cameán AM, Jos A, Prieto AI.   +4 more
europepmc   +1 more source

Distinct electrophysiology and dopaminergic modulation of medium spiny neurons across divisions of the tail striatum and the dorsolateral striatum

Experimental Physiology, EarlyView.
Abstract The striatum is a brain region within the basal ganglia that plays a crucial role in generating behaviour and mediating perception. The tail striatum (TS) is a poorly understood striatal domain with predominantly sensory functions. Recent evidence supports that abnormal TS dopamine transmission in dopaminergic disease contributes to sensory ...
Bronwyn Riley, Luke E. Hallum, Srdjan M. Vlajkovic, Johanna M. Montgomery, Peter S. Freestone   +4 more
wiley   +1 more source

SAR and QSAR Studies of Citral-Based Derivatives Against Colletotrichum fructicola. [PDF]

Chem Biodivers
Xiao M, Huang H, Wang D, Yao L, Liao S, Song J, Zeng R, Chen S.   +7 more
europepmc   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Enantioselective synthesis and characterization of [<i>m</i>.<i>n</i>]paracyclophanes. [PDF]

Chem Sci
Wen Y, Yao Y, Zhong Y, Li C, Zhao C.
europepmc   +1 more source

Dynamic memory in rodent C‐fibres and its impact on spinal nociceptive processing

The Journal of Physiology, EarlyView.
Abstract figure legend Nociceptive C‐fibres display activity‐dependent slowing (ADS) whereby successive action potentials are conducted progressively slower thus regulating the temporal relay of pain signals. This study shows that the ADS induced by short stimulus trains (which mimic stimulus evoked firing, shown in orange) is modified by prior ...
Atanaska N. Velichkova, Carole Torsney
wiley   +1 more source

Green synthesis of cadmium sulfide quantum dots coated with quercus infectoria and Heracleum persicum: cytotoxicity studies on RBCs and HFF-2 cells. [PDF]

Sci Rep
Hashemi N, Yazdinezhad A, Koushali NG, Motlagh AZ, Danafar H.   +4 more
europepmc   +1 more source